A higher circulating concentration of 25-hydroxyvitamin-D decreases the risk of renal cell carcinoma: a case-control study

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Fei LiWanLong Tan

Abstract

To investigate the relationship between vitamin D status, using circulating 25-hydroxyvitamin D [25 (OH) D], and renal cell carcinoma (RCC) risk in a case-control study, because the association between the two is unclear in China. A total of 135 incident RCC cases were matched with 135 controls by age and sex. The blood samples were collected on the first day of hospitalization before surgery to measure plasma 25 (OH) D. Logistic regression analyses were used to calculate odds ratios (ORs) and 95% confi dence intervals (95% CIs) with adjustment for several confounders (e.g. age, gender, smoking and season of blood draw). Furthermore, the association of RCC with 25 (OH) D in units of 10 ng / mL as a continuous variable were also examined. The average plasma 25 (OH) D concentrations in RCC were signifi cantly lower compared with those of the controls (21.5 ± 7.4 ng / mL vs. 24.1 ± 6.6 ng / mL, respectively; P = 0.003). In the adjusted model, inverse associations were observed between circulating 25 (OH) D levels and RCC risk for 25 (OH) D insuffi ciency (20-30 ng / mL) with OR of 0.50 (95% CI: 0.29-0.88; P = 0.015) and a normal 25 (OH) D level (≥ 30 ng / mL) with OR of 0.30 (95% CI: 0.13-0.72; P = 0.007), compared with 25 (OH) D ...Continue Reading

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Citations

Dec 10, 2020·Annals of Medicine and Surgery·Hishyar Azo NajeebQais Al Ismaeel
Jul 3, 2021·International Journal of Molecular Sciences·Anna GabryanczykAgnieszka Śliwińska
Nov 5, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jing WuMingxin Yuan

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Methods Mentioned

BETA
surgical resection
blood draw

Software Mentioned

STATA

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