A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. A prospective, controlled, feasibility study

International Journal of Cancer. Journal International Du Cancer
Zohar LeviYaron Niv

Abstract

Immunochemical fecal occult blood test (FIT) is a new colorectal cancer (CRC) screening method already recommended by the American screening guidelines. We aimed to test the feasibility of FIT as compared to guaiac fecal occult blood test (G-FOBT) in a large urban population of Tel Aviv. Average-risk persons, aged 50-75 years, were offered FIT or G-FOBT after randomization according to the socioeconomic status of their clinics. Participants with positive tests underwent colonoscopy. Participants were followed through the Cancer Registry 2 years after the study. Hemoccult SENSA™ and OC-MICRO™ (three samples, 70 ng/ml threshold) were used. FIT was offered to 4,657 persons (Group A) and G-FOBT to 7,880 persons (Group B). Participation rate was 25.9% and 28.8% in Group A and B, respectively (p < 0.001). Positivity rate in Group A and B was 12.7% and 3.9%, respectively (p < 0.001). Cancer found in six (0.49%) and eight (0.35%) patients of Group A and B, respectively (NS). Cancer registry follow-up found missed cancer in five (0.22%) cases of Group B and none in Group A (NS). The sensitivity, specificity, negative and positive predictive value for cancer in Group A and B were 100%, 85.9%, 100%, 3.9% and 61.5%, 96.4%, 99.8%, 9.1%, res...Continue Reading

References

Aug 1, 1990·Journal of Clinical Gastroenterology·Y Niv
Jan 18, 1996·The New England Journal of Medicine·J E AllisonA L Adrain
Jan 25, 2003·The American Journal of Medicine·Roanne R E SelingerJason A Dominitz
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Robert A SmithUNKNOWN American Cancer Society
Feb 26, 2003·International Journal of Nursing Terminologies and Classifications : the Official Journal of NANDA International·Young-Hee YomHyung Sook Yoo
Oct 15, 2005·Australian and New Zealand Journal of Public Health·Karen HughesBeth Newman
Feb 21, 2007·Annals of Internal Medicine·Zohar LeviYaron Niv
Sep 27, 2007·Journal of the National Cancer Institute·James E AllisonJoseph V Selby
Sep 2, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Vincent DancourtJean Faivre
Dec 25, 2008·Journal of Medical Screening·Grazia GrazziniUNKNOWN Working Group of Regional Reference Centre for Oncological Screening of Tuscany
Feb 5, 2009·Annals of Internal Medicine·Sabrina HundtHermann Brenner
Feb 26, 2009·The American Journal of Gastroenterology·Douglas K RexUNKNOWN American College of Gastroenterology

❮ Previous
Next ❯

Citations

Feb 6, 2013·Nature Reviews. Clinical Oncology·Ernst J KuipersMichael Bretthauer
Feb 24, 2012·The New England Journal of Medicine·Enrique QuinteroUNKNOWN COLONPREV Study Investigators
Apr 27, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K GarborgM Bretthauer
Jul 26, 2012·BMC Gastroenterology·Jochim S Terhaar sive DrosteChris J J Mulder
Dec 18, 2013·The American Journal of Gastroenterology·Hermann BrennerChristian Stock
May 28, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hermann Brenner, Sha Tao
Jan 15, 2016·Clinical and Translational Gastroenterology·Erin L SymondsGraeme P Young
Apr 25, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lydia GuittetGuy Launoy
Nov 26, 2015·Cancer Epidemiology·Paola ArmaroliNereo Segnan
Jun 5, 2015·Gut·Eline H SchreudersErnst J Kuipers
Aug 9, 2015·Japanese Journal of Clinical Oncology·Takahisa MatsudaYutaka Saito
May 3, 2016·Clinical Colorectal Cancer·Donna Fitzpatrick-LewisParminder Raina
Sep 7, 2014·Gut·S SanduleanuUNKNOWN Expert Working Group on ‘Right-sided lesions and interval cancers’, Colorectal Cancer Screening Committee, World Endoscopy O
Jun 11, 2015·Gut·Carlo SenoreCesare Hassan
Sep 14, 2013·Preventive Medicine·Jessica ChubakBeverly B Green
Oct 23, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean-Luc BulliardCarrie Klabunde
Mar 26, 2015·European Journal of Gastroenterology & Hepatology·Daiga SantareMarcis Leja
Nov 12, 2014·Frontiers in Public Health·Fabrizio StracciGrazia Grazzini
Feb 29, 2016·Journal of Gastrointestinal Cancer·Andrea IannoneAlfredo Di Leo
Sep 7, 2016·Canadian Journal of Gastroenterology & Hepatology·Jill TinmouthLawrence Paszat
Nov 8, 2013·Journal of Medical Screening·Nathalie J MassatStephen W Duffy
Jun 25, 2014·Journal of Medical Screening·Barcey T LevyCarol Moss
Jul 1, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Cédric RatJean-Michel Nguyen
May 31, 2018·CA: a Cancer Journal for Clinicians·Andrew M D WolfRobert A Smith
Oct 29, 2019·The American Journal of Gastroenterology·Hermann BrennerKevin Selby
Jul 2, 2014·The International Journal of Biological Markers·Yasunobu NishiokaMasao Tanaka
Jul 22, 2017·Current Gastroenterology Reports·Kevin M Rank, Aasma Shaukat
Dec 12, 2018·European Journal of Epidemiology·Carole VitelliusFrançois-Xavier Caroli-Bosc
Oct 13, 2017·Expert Review of Anticancer Therapy·Marcello MaidaGiuseppe Scarpulla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.