A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice

MicrobiologyOpen
Yuji AibaYasuhiko Komatsu

Abstract

A novel strain of Lactobacillus johnsonii No. 1088 was isolated from the gastric juice of a healthy Japanese male volunteer, and characterized for its effectiveness in the stomach environment. Lactobacillus johnsonii No. 1088 was found to have the strongest acid resistance among several lactobacilli examined (>10% of cells survived at pH 1.0 after 2 h), and such a high acid resistance property was a specific characteristic of this strain of L. johnsonii. When cultured with various virulent bacteria, L. johnsonii No. 1088 inhibited the growth of Helicobacter pylori, Escherichia coli O-157, Salmonella Typhimurium, and Clostridium difficile, in which case its effectiveness was more potent than that of a type strain of L. johnsonii, JCM2012. In addition to its effect in vitro, L. johnsonii No. 1088 inhibited the growth of H. pylori in human intestinal microbiota-associated mice in both its live and lyophilized forms. Moreover, L. johnsonii No. 1088 suppressed gastric acid secretion in mice via decreasing the number of gastrin-positive cells in the stomach. These results taken together suggest that L. johnsonii No. 1088 is a unique lactobacillus having properties beneficial for supporting H. pylori eradication by triple therapy incl...Continue Reading

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Citations

Apr 7, 2016·Best Practice & Research. Clinical Gastroenterology·Doron Boltin
Nov 19, 2015·Journal of Clinical Pathology·Alessandro Di CerboTommaso Iannitti
Sep 16, 2015·Helicobacter·Dionyssios N SgourasYoshio Yamaoka
Aug 18, 2016·Helicobacter·Chloë De WitteFreddy Haesebrouck
Jan 8, 2020·Nutrients·Jing Cheng, Arthur C Ouwehand
Feb 13, 2020·International Journal of Molecular Sciences·Jianfu Ji, Hong Yang
Jun 28, 2016·Experimental and Therapeutic Medicine·Ghalia KhoderSherif M Karam
Oct 28, 2017·Applied Microbiology and Biotechnology·Kamila GoderskaTeresa Alarcon

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Methods Mentioned

BETA
PCR
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AxioVision

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