A highly efficient Friedel-Crafts reaction of tertiary α-hydroxyesters or α-hydroxyketones to α-quaternary esters or ketones

Chemistry, an Asian Journal
Long Chen, Jian Zhou


A catalytic Friedel-Crafts arylation of α-hydroxyesters or α-hydroxyketones with electron-rich aromatic compounds to furnish α-quaternary esters/ketones has been developed. The cheap and easy to handle catalyst HClO(4) (70 %, aq) was identified as a powerful catalyst for this arylation reaction.


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Related Concepts

Hydrocarbons, Aromatic
Alpha hydroxyketone
Alpha Tocopherol
Aryl Sulfotransferase Activity

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