A highly selective and sensitive 1,8-naphthalimide-based fluorescent sensor for Zn2+ imaging in living cells

Bioorganic & Medicinal Chemistry Letters
Daying LiuHuarui He

Abstract

A new 4-amino-1,8-naphthalimide-based fluorescent sensor, with iminoacetic acid and iminoethoxyacetic acid as receptor, was developed. It was applied successfully to detect Zn2+ in aqueous solution and living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn2+ with about 7-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1,8-naphthalimide with a green color centered at 550 nm.

References

Feb 20, 1989·Brain Research·C J FredericksonJ F McGinty
Feb 6, 2003·Journal of the American Chemical Society·Huarui HeJames K Tusa
Feb 15, 2003·Analytical Chemistry·Huarui HeJames K Tusa
Oct 31, 2003·Organic & Biomolecular Chemistry·Thorfinnur GunnlaugssonRaman Parkesh
Mar 11, 2008·Analytica Chimica Acta·Huarui HeChao Lin
Jun 6, 2008·Angewandte Chemie·Hwan Myung KimBong Rae Cho
Nov 18, 2009·The Analyst·A Prasanna de SilvaGlenn D Wright
Feb 24, 2010·Chemical Communications : Chem Comm·Zhaochao XuDavid R Spring
Apr 30, 2010·Chemical Society Reviews·Zhaochao XuDavid R Spring
Mar 28, 2012·Chemical Communications : Chem Comm·Na Young BaekHwan Myung Kim
Jul 28, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Ji-An ZhouDe-Cheng Bai
Aug 27, 2014·Metallomics : Integrated Biometal Science·Anne M Hessels, Maarten Merkx
Feb 20, 2015·Chemical Society Reviews·Brian DalyA Prasanna de Silva
Mar 10, 2015·Chemical Society Reviews·Yuncong ChenZijian Guo
Oct 12, 2017·Chemical Society Reviews·Di WuTony D James

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.