A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver

Toxicology Letters
K MatsusueK Oguri

Abstract

The changes in lipid metabolism produced by a coplanar PCB were studied in rats. Male Wistar rats were given a single intraperitoneal injection of 3,3',4,4',5-pentachlorobiphenyl at a dose of 25 mg/kg. After 5 days of administration, total hepatic lipids were treated with 1 M KOH in methanol at 75 degrees C and the liberated fatty acids were analyzed by HPLC after conversion to fluorescent derivatives. In comparison with free-fed and pair-fed control groups, the proportion of arachidonic acid in the PenCB-treated rats was reduced by about 50%, while oleic and linoleic acids increased significantly. We also examined the individual glycerophospholipids, separated by TLC, to see if they were affected by alteration in the fatty acid composition of the whole liver. In all glycerophospholipids, the proportion of arachidonic acid was reduced significantly to the same degree while linoleic acid increased. Changes in the activity of desaturase isozymes have been postulated to explain this unusual lipid metabolism following administration of a toxic PCB and this may contribute to its toxicity.

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Citations

Mar 17, 2004·Toxicology Letters·Kierstin Petersson GrawéAgneta Oskarsson
Nov 9, 2001·Journal of Toxicology and Environmental Health. Part a·R KäkeläJ Asikainen
Apr 17, 2012·Journal of Pharmaceutical and Biomedical Analysis·Jie ZhangHeqing Shen
Jun 19, 2015·Environmental Research·Sandra Søgaard TøttenborgPhilippe Grandjean
May 10, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meng-Chuan HuangShu-Li Wang
Mar 4, 2000·Chemico-biological Interactions·E SánchezM A Pérez-Albarsanz
Feb 26, 2003·The American Journal of Clinical Nutrition·Philippe Grandjean, Pál Weihe
Jan 16, 1999·Journal of Biochemical and Molecular Toxicology·B HennigL W Robertson

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