Jul 1, 1977

A histamine-induced decrease of action potential duration in cardiac muscle mediated by the H2 receptors

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F LeddaL Mantelli


The effects of histamine (10(-7)--10(-5) M) on the cardiac action potential have been studied in ventricular strips of guinea pig heart, electrically driven at a constant rate. A decrease of action potential was constantly observed at histamine concentrations above 10(-6) M. No significant variations of the other electrophysiological parameters were induced by the amine. The decrease in the duration of the action potential was blocked by burimamide at a concentration (10(-4) M) which induced only a slight changes in action potential outline. It is suggested that the shortening of the repolarization phase induced by histamine is due to the H2 receptor-mediated activation of the calcium inward current, which can increase the intracellular calcium concentration influencing the potassium permeability.

Mentioned in this Paper

Histamine Measurement
Calcium [EPC]
Histamine H2 Receptors
Depression, Chemical
Action Potentials

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