A histological and functional description of the tissue causing chronic postthrombotic venous obstruction

Thrombosis Research
Anthony J ComerotaFedor Lurie

Abstract

Postthrombotic intraluminal tissue causing postthrombotic syndrome (PTS) has not been well described. This study defines its histological characteristics and assess whether tissue function evolves over time. Specimens from 18 common femoral veins (CFV) from 16 patients obtained during CFV endovenectomy and iliocaval recanalization were examined. Phase 1 used hematoxylin and eosin and Masson's trichrome stains for collagen, immunohistochemical, and Von Kossa stains. Phase 2 examined young (≤ one year) and mature (≥10years from acute DVT) specimens to evaluate evolution of endothelial function. Antibodies to four biomarkers were used to examine specific functions of endothelial cells lining neovessels and recanalization channels (RC). Phase 1: Specimens demonstrated 80-90% of collagen type I, 10-20% of collagen type III, and dystrophic calcification. Neovessels and RC were in close proximity to each other. Thrombus and smooth muscle cells were absent, but white blood cells were present. Phase 2: VEGFR2 receptor uptake was more abundant in neovessels than RC and more prominent in younger specimens. Neovascular, nonchannel cells were observed more frequently in young specimens. CD-31 was similar in young and mature specimens. TIE-2...Continue Reading

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Citations

Oct 16, 2015·Blood Reviews·Arina J ten Cate-HoekThomas W Wakefield
Sep 18, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Katherine A GallagherPeter K Henke
Mar 9, 2018·Phlebology·Timme Maj van VuurenCees Ha Wittens
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Nov 5, 2020·Journal of the American College of Emergency Physicians Open·Brian J Ahern, Michael D Perreault
Feb 5, 2021·Research and Practice in Thrombosis and Haemostasis·John W Weisel, Rustem I Litvinov
May 10, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Arshpreet Singh BadeshaTaha Khan
Aug 12, 2021·Journal of Thrombosis and Thrombolysis·Shanshan ShenYingmin Chen

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