Abstract
We compared histologic, immunohistochemical, and vascular findings in synovial biopsies from individuals with Gulf War Veterans Illness and joint pain (GWVI) to findings in normal and osteoarthritis (OA) synovium. The following parameters were assessed in synovial biopsies from ten individuals with GWVI: lining thickness, histologic synovitis score, and vascular density in hematoxylin & eosin-stained sections; and CD68+ lining surface cells and CD15+, CD3+, CD8+, CD20+, CD38+, CD68+, and Ki-67+ subintimal cells and von Willebrand Factor+ vessels immunohistochemically. Comparisons were made to synovial specimens from healthy volunteers (n = 10) and patients with OA or RA (n = 25 each). Histologic appearance and quantitative assessments were nearly identical in the GWVI and normal specimens. Vascular density was between 25% (H & E stains; p = 0.003) and 31% (vWF immunostains; p = 0.02) lower in GWVI and normal specimens than in OA. CD68+ macrophages were the most common inflammatory cells in GWVI (45.3 +/- 10.1 SEM cells/mm(2)) and normal synovium (45.6 +/- 7.4) followed by CD3+ T cells (GWVI, 15.1 +/- 6.3; normal, 27.1 +/- 9.2), whereas there were practically no CD20+, CD38+, and CD15+ cells. All parameters except lining thickne...Continue Reading
References
Mar 6, 1998·Archives of Internal Medicine·E P GradyD F Battafarano
Jul 3, 1999·Journal of Occupational and Environmental Medicine·M J Hodgson, H M Kipen
Jul 3, 2002·Pathology, Research and Practice·V KrennA König
Jun 15, 2004·Annals of the Rheumatic Diseases·J A SinghH R Schumacher
Jul 21, 2004·Annals of Internal Medicine·Sam T DontaUNKNOWN VA Cooperative #475 Group
Aug 5, 2004·Rheumatology·C S Bonnet, D A Walsh
Jun 21, 2005·Zeitschrift für Rheumatologie·V KrennT Häupl
Jul 28, 2005·Current Rheumatology Reports·Tai Teck LeongDouglas J Veale
May 12, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark PeakmanMatthew Hotopf
Jun 3, 2006·Clinical Rheumatology·Nicola MaruottiDomenico Ribatti
Sep 19, 2006·Histopathology·V KrennT Haupl
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Reng-Rong DaYiping Zhang
Jul 7, 2007·Annals of the Rheumatic Diseases·F PesslerH R Schumacher
Oct 2, 2007·Arthritis and Rheumatism·C Diaz-TorneF Pessler
Jan 22, 2008·Annals of the Rheumatic Diseases·F PesslerH R Schumacher
Citations
May 15, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yamini AchariDavid A Hart
Sep 3, 2013·Neurotoxicology·T J NutterBrian Y Cooper
Feb 12, 2010·Pediatric Rheumatology Online Journal·Normi BruckFrank Pessler
Aug 21, 2013·PloS One·Cristina Della BeffaFrank Pessler
Apr 16, 2014·Toxicology and Applied Pharmacology·Thomas J Nutter, Brian Y Cooper
Aug 1, 2008·Arthritis and Rheumatism·F PesslerH R Schumacher
Sep 11, 2012·Osteoarthritis and Cartilage·B J E de Lange-BrokaarM Kloppenburg
Nov 30, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Frank PesslerH Ralph Schumacher
Aug 2, 2012·Ultrastructural Pathology·Li Yun ZhangH Ralph Schumacher
Nov 28, 2014·Journal of the Royal Army Medical Corps·Luca RoncatiA Maiorana
Jun 13, 2015·Journal of Immunology Research·Adrese M KandahariQuanjun Cui
Jun 22, 2014·Tissue Engineering. Part B, Reviews·Niamh FahyJ Mary Murphy
May 20, 2016·Stem Cell Research & Therapy·Eric FarrellJ Mary Murphy
Jun 23, 2016·Scottish Medical Journal·S M HussainRmd Meek
Nov 4, 2017·Current Osteoporosis Reports·Erika Barboza Prado LopesMary Beth Humphrey
Jun 3, 2010·The Journal of Rheumatology·Alexis OgdieFrank Pessler
Nov 17, 2009·Clinical Psychology & Psychotherapy·Bryany CusensVidyamala Burch
Nov 1, 2018·Revista Brasileira De Ortopedia·Gustavo Göhringer de Almeida BarbosaCristiano Valter Diesel
Apr 25, 2019·Scandinavian Journal of Immunology·Meenakshi SachdevaAnjali Aggarwal
Jul 4, 2019·Journal of Clinical Nursing·Sajed Faisal GhawadraCheng Kar Phang
Nov 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bruno C MenarimLinda A Dahlgren
Nov 18, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A OgdieFrank Pessler
Jun 12, 2019·Journal of Inflammation·Qihong QueShuanglin Wan
Apr 21, 2017·Frontiers in Immunology·Yu-Sheng LiGuang-Hua Lei
Jan 11, 2017·International Journal of Rheumatology·Jirun ApinunRangsima Reantragoon
Aug 6, 2019·Frontiers in Immunology·Carla AlvarezAlpdogan Kantarci
Feb 6, 2021·International Journal of Molecular Sciences·Davor CaricKatarina Vukojevic
Dec 17, 2020·Frontiers in Veterinary Science·Bruno C MenarimLinda A Dahlgren
Jan 26, 2021·Rheumatology·Hao WangHua Wang
Mar 21, 2021·Life Sciences·Emily G GeanShannon M Nugent
Apr 13, 2021·Human Gene Therapy·Ashley D CameronKyla F Ortved
Aug 10, 2021·World Journal of Stem Cells·Bruno C MenarimLinda A Dahlgren
Nov 6, 2021·Scientific Reports·Eleonora OlivottoRosa Maria Borzì