PMID: 8440819Feb 1, 1993Paper

A histomorphometric comparison of bone in young growing rats fed an elemental diet versus a chemically defined polymeric diet

Journal of the American College of Nutrition
P T LawsonE W Lipkin

Abstract

This study was designed to examine whether a synthetic elemental diet, which could be adapted for total parenteral nutrition, is capable of promoting bone growth comparable to a commercially available liquid polymeric diet. The orally fed young rat was chosen as a model of rapid bone growth. Sixteen male, Wag/Rij rats weighing 120 +/- 3 g were divided into two groups of eight rats each. One group was fed an elemental diet formulated to approximate the nutritional requirements of the rat as recommended by the National Research Council. The comparison group received a liquid polymeric diet. After 14 days there were no significant differences between groups in femur and tibia weights, cortical and medullary area, periosteal and endosteal label area, growth plate width, percent cancellous bone, bone apposition rates and osteoblasts and osteoclasts per millimeter. Both groups maintained a positive calcium and nitrogen balance. These data indicate that bone growth, structure and remodeling comparable to that seen in a polymeric-fed comparison group can be achieved in young rats when fed an oral dextrose/amino acid-based elemental solution for 2 weeks.

References

Jan 1, 1991·Critical Reviews in Food Science and Nutrition·M TorreF Saura-Calixto
Nov 1, 1989·The American Journal of Clinical Nutrition·S A SchuetteH E Ford
Jul 1, 1989·AJR. American Journal of Roentgenology·W F Coughlin, S K McMurdo
Jan 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·M B PoppS D Morrison
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·H TakeyamaF Kato
Jan 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·F M MartinsL Lindmark
May 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·J KurkusM E Shils
Jul 1, 1984·The American Journal of Clinical Nutrition·R J WoodI H Rosenberg
Jul 1, 1984·The American Journal of Clinical Nutrition·M B Popp, S C Wagner
Dec 1, 1982·The American Journal of Clinical Nutrition·M B PoppM F Brennan
Apr 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·G S RANHOTRA, B C JOHNSON

❮ Previous
Next ❯

Citations

Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Cohen-SolalB Messing
Jun 15, 2007·Toxicology·Malgorzata M BrzóskaJanina Moniuszko-Jakoniuk
Jan 1, 1996·American Journal of Primatology·Edward W Lipkin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.