A histopathologic screening method for rational use of organs from prostate-specific antigen-positive multiorgan donors: the Italian Emilia-Romagna Region experience

Transplantation
Antonia D'Errico GrigioniItalian Emilia-Romagna Region experience

Abstract

Reduction of waiting-list length requires extension of the organ-donor pool to elderly males bearing an higher risk of prostate cancer incidence. Prostate-cancer screening in organ donors is currently based on prostate-specific antigen (PSA) assays (total PSA and free/total PSA). However, the specificity of these assays is restricted, limiting risk-benefit analysis. Since 2001, 33 multiorgan donor candidates presenting within Emilia-Romagna (Italy) with suspect ultrasonography or abnormal PSA values were submitted to a histopathologic screening method of the entire prostate based on extemporary frozen-section analysis (maximum 1 hour) of over 50% of the organ at 0.1 mm cutting levels. Extemporary diagnosis of adenocarcinoma was made in 12 (36%) cases, corresponding to 4.5% of the male candidates aged more than 50 years in the donor pool. In all cases, the final diagnosis confirmed the extemporary analysis. As well as maximizing safety, this novel approach should permit more refined risk-benefit analysis.

References

Jul 11, 2000·Archives of Pathology & Laboratory Medicine·D G BostwickJ W Yarbro
Jun 4, 2002·Transplantation·Robin F JeffreyCharles G Newstead
Jul 19, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A MicheliUNKNOWN EUROPREVAL Working Group
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A VerdecchiaUNKNOWN EUROPREVAL Working Group
Aug 15, 2002·Transplantation·H Myron KauffmanAllan M Roza
Dec 23, 2003·Transplantation·Michelangelo FiorentinoWalter F Grigioni

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Citations

Jul 31, 2007·Journal of Clinical Pathology·Roberta MazzucchelliRodolfo Montironi
Dec 11, 2013·Transplantation Reviews·Arnaud DoerflerHenri Bensadoun
Dec 9, 2008·Pathology, Research and Practice·Giovanni FalconieriStefano Pizzolitto
Aug 16, 2015·Transplantation Reviews·S DholakiaJ Crane
Jul 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D'Errico-GrigioniNicola Alvaro
Aug 9, 2016·Transplantation Proceedings·K PabisiakK Ciechanowski
Oct 12, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·R ThuretM O Timsit

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