Abstract
To clarify the relationship between hepatitis C virus infection and excessive alcohol intake, we carried out histological examination of the liver in 46 alcoholics with chronic hepatitis C virus infection and compared the findings in 55 patients with chronic hepatitis C, 38 with alcoholic liver disease, and 27 with chronic hepatitis B. The majority of alcoholics with chronic hepatitis C virus infection displayed virus-related histological changes very similar to those in chronic hepatitis C, including frequent lymphoid follicles (34.7%) or aggregates (93.3%) in the portal tracts, mild necroinflammatory change (76.1%) in the parenchyma, and lymphocytosis in sinusoids (83.7%). Liver cell dysplasia and irregular regenerative activity of hepatocytes were rarely observed. The effects of alcohol on the liver were found to be minimal in the majority. These findings could suggest that the hepatic injury in the majority of alcoholics with chronic hepatitis C virus infection in Japan is due to persistent hepatitis C virus infection rather than to alcoholic injury. In addition, our study disclosed that the perivenular fibrosis which is designated as a histological characteristic of alcoholic liver disease is frequently observed in chronic...Continue Reading
References
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J ScheuerG M Dusheiko
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N BachF Schaffner
Sep 1, 1991·Digestive Diseases and Sciences·T TakahashiF Ichida
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ParésJ Rodés
Oct 1, 1987·Liver·T UchidaI Kronborg
Sep 14, 1968·Lancet·J De GrooteE Uehlinger
Jun 1, 1972·Human Pathology·M Schmid, B Cueni
Jun 1, 1972·Human Pathology·H Poulsen, P Christoffersen
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H P DienesH Lobeck
Feb 1, 1993·Gastroenterology·J H LefkowitchJ L Dienstag
Nov 1, 1963·Annals of Internal Medicine·H A EDMONDSONO T KUZMA
Citations
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F PessioneB Rueff
Mar 2, 2006·Digestive Diseases·M Mazen JamalTimothy R Morgan
Nov 12, 2015·World Journal of Gastroenterology : WJG·María Martínez-EsparzaPilar García-Peñarrubia
Jun 26, 1998·Journal of Gastroenterology and Hepatology·M H KhanG C Farrell
Sep 7, 2001·Transplantation·C O BellamyA J Demetris
Jul 13, 1999·Transplantation·H S ConjeevaramA L Baker
Feb 19, 2003·Journal of Clinical Gastroenterology·Renuka Bhattacharya, Margaret C Shuhart
Jan 25, 2003·Journal of Clinical Gastroenterology·Miguel A SerraJosé M Rodrigo
Apr 7, 2007·Digestive Diseases and Sciences·Ahmad Kamal, Ramsey Cheung
Dec 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James E Everhart, Elizabeth C Wright
Aug 19, 2007·Journal of Clinical Gastroenterology·Ashwani K Singal, Bhupinder S Anand
Mar 1, 2007·Scandinavian Journal of Gastroenterology·Massimo BolognesiAngelo Gatta
Oct 6, 1997·Journal of Hepatology·G CorraoF di Orio
Aug 19, 2007·Free Radical Biology & Medicine·Scott SeronelloJinah Choi
Nov 24, 2006·Virology Journal·Sharon L LedererMichael G Katze