A histoquantitative study of the striate cortex and lateral geniculate body in normal, blind and demented subjects

Neuropathology and Applied Neurobiology
C L ScholtzD M Mann

Abstract

The amount of myelin in the outer band of Baillarger in the human visual cortex stained by Luxol Fast Blue MBS, has been measured in normal individuals of wide age range, in a group of blind and severely visually impaired but otherwise normal individuals and in a series of demented patients of the Alzheimer and multi-infarct type who were apparently visually normal. The amount of myelin is found to be significantly reduced in the blind and demented groups. Examination of the lateral geniculate body in the blind cases demonstrated slight reduction in neuron numbers and marked reduction in mean neuron diameter. Neuronal cytoplasmic ribonucleic acid, nucleolar volume and numbers of tetraploid glial nuclei in the blind or visually impaired cases were significantly reduced when compared with controls, indicating reduced function in these neurons. Similar results were obtained on examining this nucleus in Alzheimer and multi-infarct cases, suggesting that the visual pathways may be involved in these conditions. It is concluded that loss of myelin from the outer band of Baillarger occurs in association with reduced function of neurons in the lateral geniculate body.

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Citations

Mar 1, 1993·Annals of Neurology·C A Curcio, D N Drucker
Feb 12, 2011·Cerebral Cortex·Robert TrampelRobert Turner
Jun 1, 1995·The British Journal of Ophthalmology·D C DaviesK A Jobst
Dec 7, 2013·Survey of Ophthalmology·Radouil Tzekov, Michael Mullan
Aug 15, 1993·American Journal of Ophthalmology·N ChaturvediE B Dreyer
Jul 1, 1989·Survey of Ophthalmology·B Katz, S Rimmer
May 1, 1982·Neuropathology and Applied Neurobiology·D M Mann
Jun 15, 1988·The Journal of Comparative Neurology·R W Williams, P Rakic
Oct 1, 1986·Annals of Neurology·W A Fletcher, J A Sharpe
Oct 1, 1986·Annals of Neurology·B T HymanA R Damasio

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