A history of our understanding of cerebral vascular development and pathogenesis of perinatal brain damage over the past 30 years

Seminars in Pediatric Neurology
Sachio TakashimaAkira Oka

Abstract

This article reviews our studies focusing on cerebral vascular development, the pathogenesis of subependymal/intraventricular hemorrhage (SEH/IVH), periventricular leukomalacia (PVL), and pontosubicular neuron necrosis (PSN). Their pathogenesis consists of predisposing developmental and causal factors. SEH/IVH may be caused by reperfusion or overperfusion following ischemia in the subependymal germinal matrix with characteristic vasculature. The cause of PVL is multifactorial (ie, ischemia and inflammation), predisposed by the maturational status of the vasculature and oligodendroglia in the white matter. Focal PVL is ischemic necrosis, and diffuse PVL or white matter injury may include cytotoxic damage. PSN has an apoptotic character, and may be induced by ischemic and oxidative stress on specific immature neurons. Further studies on preventive and therapeutic measures are necessary in clinical, pathologic, and experimental fields. The monitoring and control methods of brain hemodynamics and cellular stability should be more developed to prevent brain damages.

References

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Citations

Jul 9, 2013·Neuroradiology·Charles RaybaudMutaz Al Nassar
Dec 17, 2010·Developmental Neuroscience·Jamie WrightSteven G Kernie
Aug 2, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C A HillR H Fitch
Apr 9, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C A HillR H Fitch
Dec 3, 2010·Developmental Medicine and Child Neurology·Inga KoerteFlorian Heinen
Jul 21, 2010·Paediatric Anaesthesia·Jerrold LermanDavid J Steward
Dec 3, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Chieko HisamatsuEiji Nishijima
May 23, 2015·Translational Stroke Research·Ijeoma EsiabaDanilo S Boskovic
Oct 23, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Linda M ErnstDebra E Weese-Mayer
Feb 14, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Baptiste PortePhilippe Leroux
Oct 21, 2016·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Kaori TamuraKeiji Iramina
Jul 21, 2017·The Cochrane Database of Systematic Reviews·Olga RomantsikMatteo Bruschettini
Jun 20, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C A NettoS V Sizonenko
Jul 9, 2020·The Cochrane Database of Systematic Reviews·Olga RomantsikMatteo Bruschettini
Aug 23, 2019·International Journal of Molecular Sciences·Herong CuiHaimin Lei

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