A holey pursuit: lumen formation in the developing kidney

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Denise K Marciano

Abstract

The formation of polarized epithelial tubules is a hallmark of kidney development. One of the fundamental principles in tubulogenesis is that epithelia coordinate the polarity of individual cells with the surrounding cells and matrix. A central feature in this process is the segregation of membranes into spatially and functionally distinct apical and basolateral domains, and the generation of a luminal space at the apical surface. This review examines our current understanding of the cellular and molecular mechanisms that underlie the establishment of apical-basal polarity and lumen formation in developing renal epithelia, including the roles of cell-cell and cell-matrix interactions and polarity complexes. We highlight growing evidence from animal models, and correlate these findings with models of tubulogenesis from other organ systems, and from in vitro studies.

References

Feb 1, 1991·The American Journal of Physiology·A K WilsonP De Lanerolle
May 1, 1987·Kidney International·J J GranthamA P Evan
Jan 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L LaitinenL Saxén
May 15, 1966·International Journal of Cancer. Journal International Du Cancer·L Saxen, J Wartiovaara
May 1, 1982·The Journal of Cell Biology·D A HerzlingerG K Ojakian
Jan 1, 1984·Cell and Tissue Research·T BärJ R Wolff
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P EkblomL Saxén
Jan 27, 1998·Current Opinion in Nephrology and Hypertension·J H Miner
Nov 24, 1999·The Journal of Clinical Investigation·Y Huan, J van Adelsberg
Jul 4, 2001·The Journal of Experimental Medicine·R DoyonnasK M McNagny
Jul 18, 2001·The Journal of Clinical Investigation·T TakedaM G Farquhar
Feb 13, 2002·Molecular and Cellular Biology·Ulf DahlHenrik Semb
Feb 16, 2002·Developmental Biology·Ming-Jer TangGregory R Dressler
Nov 21, 2002·Trends in Cell Biology·Matthew Buechner
Jan 16, 2003·Cell·Barry Lubarsky, Mark A Krasnow
Apr 1, 1956·Experimental Cell Research·C GROBSTEIN
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Sandra SchmiederMarilyn G Farquhar
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cristina CebriánDoris A Herzlinger
Dec 13, 2005·American Journal of Physiology. Renal Physiology·David B N LeeHarry J Ward
Oct 20, 2006·PLoS Biology·Arjun RajSanjay Tyagi
Sep 11, 2007·Developmental Biology·Heather A HartmanLarry T Patterson
Mar 19, 2008·Gene Expression Patterns : GEP·M Todd Valerius, Andrew P McMahon
Apr 4, 2008·Journal of the American Society of Nephrology : JASN·Baoxue YangA S Verkman
Apr 9, 2008·Current Biology : CB·Fernando Martín-BelmonteKeith Mostov
Jul 30, 2008·The Journal of Cell Biology·Caroline MedioniMichel Sémériva

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Citations

Apr 21, 2018·The Journal of Biological Chemistry·Chika TakahashiEisuke Nishida
Jan 14, 2018·Genes & Development·D Berfin AzizogluOndine Cleaver
Apr 22, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Loren W Runnels, Yuko Komiya
Oct 24, 2020·Tissue Barriers·Joseph M Chambers, Rebecca A Wingert
Aug 3, 2021·Cells & Development·Alejandro Torres-SánchezGuillaume Salbreux

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