A homologue gene of β-catenin participates in the development of shrimps and immune response to bacteria and viruses

Fish & Shellfish Immunology
Ya-Kai XieCui-Jie Kang

Abstract

β-Catenin is a multifunctional protein that is involved in many physiological processes, including development, cell proliferation, cell migration, and apoptosis. However, the function of β-Catenin in crustacean is unknown. In this study, the first shrimp homologous gene of β-catenin in Marsupenaeus japonicus (i.e., Mjβ-catenin) was identified and characterized. The full-length of the complementary DNA of Mjβ-catenin is 3130 bp, including a 2463 bp open reading frame that encodes 821 amino acid. Multiple alignment of β-Catenin proteins suggested that the Armadillo/β-Catenin-like repeat domains were conserved. Phylogenetic analysis showed that β-Catenin from shrimp was clustered into one group with invertebrate β-Catenin. The transcription of β-catenin in various development stages of shrimp was detected and persistently increased as the shrimp matured. In adult shrimp, β-catenin was widely distributed in detected tissues and has the relatively high expression level in gills, hemocytes, testes, and ovaries. The transcripts of β-catenin in tissues of adult shrimp were significantly up-regulated at various time points after infecting with Staphylococcus aureus, Vibrio anguillarum, and white-spot syndrome virus. Furthermore, knockd...Continue Reading

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