PMID: 2509484Nov 1, 1989Paper

A homologue of the axonally secreted protein axonin-1 is an integral membrane protein of nerve fiber tracts involved in neurite fasciculation

The Journal of Cell Biology
M A RueggP Sonderegger

Abstract

Axonin-1 is a glycoprotein that is released from axons of cultured neurons (Stoeckli, E. T., P. F. Lemkin, T. B. Kuhn, M. A. Ruegg, M. Heller, and P. Sonderegger. 1989. Eur. J. Biochem. 180:249-258). It has recently been purified from the ocular vitreous fluid of the chicken embryo (Ruegg, M. A., E. T. Stoeckli, T. B. Kuhn, M. Heller, R. Zuellig, and P. Sonderegger. 1989. EMBO (Eur. Mol. Biol. Organ.) J. 8:55-63). Immunohistochemistry localized axonin-1 prevalently in developing nerve fiber tracts. The presence of anti-axonin-1 Fab fragments during axon growth in vitro resulted in antibody binding to the axonal surfaces and in a marked perturbation of the fasciculation pattern. Hence, a fraction of axonin-1 is associated with axonal membranes and, by operational criteria, qualifies as a cell adhesion molecule. The major proportion of membrane-associated axonin-1 co-solubilized with the integral membrane proteins. By physico-chemical, immunological, and protein-chemical criteria, the integral membrane form was found to be highly similar to soluble axonin-1. In common with a number of other cell adhesion molecules, both soluble and membrane-bound axonin-1 express the L2/HNK-1 and the L3 epitopes. Radioactive pulse-chase and doubl...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R B Campenot
Jan 1, 1979·Annual Review of Biochemistry·W Frazier, L Glaser
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1986·The Journal of Cell Biology·S S CarlsonR B Kelly
Jun 1, 1987·The Journal of Cell Biology·A KüchererM Schachner
Jan 1, 1988·The Journal of Cell Biology·V KünemundM Schachner
Jan 24, 1989·Biochemistry·J F Hare, E Lee
Dec 1, 1987·The Journal of Cell Biology·R M NitkinU J McMahan
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P M SnowC S Goodman
Nov 1, 1988·The Journal of Cell Biology·C Magill-Solc, U J McMahan
Aug 1, 1988·Neuron·R B Kelly
Mar 15, 1989·European Journal of Biochemistry·E T StoeckliP Sonderegger
Jan 1, 1988·Annual Review of Biochemistry·M A Ferguson, A F Williams
Feb 1, 1986·The Journal of Cell Biology·D R FriedlanderG M Edelman
Feb 1, 1987·The Journal of Cell Biology·F G RathjenU Rutishauser
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W B Stallcup, L Beasley
Mar 1, 1973·Archives of Biochemistry and Biophysics·P BöhlenS Udenfriend
Jan 1, 1973·Journal of Supramolecular Structure·T L Steck, J Yu
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Jul 1, 1980·Analytical Biochemistry·B R OakleyN R Morris
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M GrumetG M Edelman
Feb 1, 1984·The Journal of Cell Biology·A Krystosek, N W Seeds
Jan 1, 1984·The Journal of Cell Biology·P SondereggerP G Nelson
Oct 1, 1980·Journal of Neurochemistry·H Rohrer, M Schachner
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R BehraP Sonderegger
Jan 1, 1982·Analytical Biochemistry·R HawkesJ Gordon
Sep 25, 1981·Science·A Krystosek, N W Seeds

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Citations

Mar 5, 1998·Journal of Neuroscience Research·Y KameiK Watanabe
Mar 18, 1994·Brain Research. Developmental Brain Research·W HalfterJ W Yip
Apr 1, 1995·Trends in Neurosciences·M Schachner, R Martini
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M CervelloU Rutishauser
Dec 1, 1990·The Journal of Cell Biology·F Keller, S Schacher
Feb 1, 1991·The Journal of Cell Biology·E T StoeckliP Sonderegger
May 1, 1992·The Journal of Cell Biology·P DurbecG Rougon
Jan 15, 1993·European Journal of Biochemistry·T H HaslerP Sonderegger
Feb 1, 1995·European Journal of Biochemistry·R J GigerP Sonderegger
Dec 16, 1998·The Journal of Cell Biology·S KunzP Sonderegger
Oct 1, 1993·European Journal of Biochemistry·B Ganss, W Hoffmann
Jul 1, 1993·European Journal of Biochemistry·C RaderP Sonderegger
Dec 1, 1994·The Anatomical Record·U Drenhaus, G Rager
Aug 1, 1992·Journal of Neurobiology·H C TsuiW L Klein
Aug 4, 2006·Glia·Ina B WannerKristján R Jessen
Apr 16, 2010·The Journal of Comparative Neurology·Shizuko MurakamiKatsuhiko Ono
Mar 15, 1989·European Journal of Biochemistry·E T StoeckliP Sonderegger
Mar 6, 2003·Gene Expression Patterns : GEP·Kostas TheodorakisDomna Karagogeos

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