A host immune hormone modifies parasite species interactions and epidemics: insights from a field manipulation

Proceedings. Biological Sciences
Fletcher W HallidayCharles E Mitchell

Abstract

Parasite epidemics can depend on priority effects, and parasite priority effects can result from the host immune response to prior infection. Yet we lack experimental evidence that such immune-mediated priority effects influence epidemics. To address this research gap, we manipulated key host immune hormones, then measured the consequences for within-host parasite interactions, and ultimately parasite epidemics in the field. Specifically, we applied plant immune-signalling hormones to sentinel plants, embedded into a wild host population, and tracked foliar infections caused by two common fungal parasites. Within-host individuals, priority effects were altered by the immune-signalling hormone, salicylic acid (SA). Scaling up from within-host interactions, hosts treated with SA experienced a lower prevalence of a less aggressive parasite, increased burden of infection by a more aggressive parasite, and experienced fewer co-infections. Together, these results indicate that by altering within-host priority effects, host immune hormones can drive parasite epidemics. This study therefore experimentally links host immune hormones to within-host priority effects and parasite epidemics, advancing a more mechanistic understanding of how...Continue Reading

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Citations

Mar 5, 2020·Proceedings. Biological Sciences·Patrick A ClayVolker H W Rudolf
Jun 11, 2020·Parasitology·Tara E Stewart Merrill, Pieter T J Johnson
Sep 24, 2020·Proceedings. Biological Sciences·Laura J A van DijkAyco J M Tack
Sep 2, 2020·Nature Ecology & Evolution·Fletcher W HallidayAnna-Liisa Laine
Nov 16, 2020·Ecology·Tara E Stewart MerrillCarla E Cáceres
Mar 20, 2021·Molecular Ecology·Kayleigh R O'KeeffeCharles E Mitchell
Aug 11, 2021·Proceedings. Biological Sciences·Kayleigh R O'KeeffeCharles E Mitchell

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