A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation

PloS One
Katherine Angela BensonAmy Jayne McKnight

Abstract

New onset diabetes after transplantation (NODAT) is a serious complication following solid organ transplantation. There is a genetic contribution to NODAT and we have conducted comprehensive meta-analysis of available genetic data in kidney transplant populations. Relevant articles investigating the association between genetic markers and NODAT were identified by searching PubMed, Web of Science and Google Scholar. SNPs described in a minimum of three studies were included for analysis using a random effects model. The association between identified variants and NODAT was calculated at the per-study level to generate overall significance values and effect sizes. Searching the literature returned 4,147 citations. Within the 36 eligible articles identified, 18 genetic variants from 12 genes were considered for analysis. Of these, three were significantly associated with NODAT by meta-analysis at the 5% level of significance; CDKAL1 rs10946398 p = 0.006 OR = 1.43, 95% CI = 1.11-1.85 (n = 696 individuals), KCNQ1 rs2237892 p = 0.007 OR = 1.43, 95% CI = 1.10-1.86 (n = 1,270 individuals), and TCF7L2 rs7903146 p = 0.01 OR = 1.41, 95% CI = 1.07-1.85 (n = 2,967 individuals). Evaluating cumulative evidence for SNPs associated with NODAT i...Continue Reading

References

Feb 28, 2004·Diabetes Care·Jaime A DavidsonUNKNOWN International Expert Panel on New-Onset Diabetes after Transplantation
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Citations

Apr 1, 2017·Canadian Journal of Diabetes·Maciej TarnowskiAndrzej Pawlik
Feb 26, 2019·Transplantation·William S OettingUNKNOWN DeKAF Genomics and GEN-03 Investigators
Jul 10, 2019·Transplantation·Mamatha BhatJohane Allard
Sep 12, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Caragh P StapletonPaul J Phelan
Nov 11, 2017·Current Transplantation Reports·William S OettingPamala A Jacobson
Oct 19, 2019·Journal of Clinical Medicine·Hyeon Seok HwangUNKNOWN Korean Organ Transplantation Registry Study Group
Nov 29, 2020·Endocrine Reviews·Mamatha BhatMinna Woo
Apr 4, 2021·International Journal of Molecular Sciences·Jacek RyszAnna Gluba-Brzózka
Apr 15, 2018·Journal of Cardiothoracic and Vascular Anesthesia·Vikaesh MoorthySophia Tsong Huey Chew

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Methods Mentioned

BETA
genotyping

Software Mentioned

Google Scholar
NODAT
Review Manager

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