PMID: 6785361Apr 1, 1981Paper

A human dispermic chimaera first suspected from analyses of the blood group gene-specified glycosyltransferases

Journal of Immunogenetics
W M WatkinsW Loeb

Abstract

The red cells of a normal male blood donor, K.S., were first grouped as B but he was found to lack anti-A in his serum. Closer investigation revealed that his red cells had very weak A activity, demonstrable only by absorption and elution of anti-A. He is a non-secretor of ABH and a secretor of Lea. Blood group A-, B and H-gene specified glycosyltransferases were detected in his serum. In contrast to the finding of a B antigen of normal strength on his red cells, the B transferase in his serum was only about 30% of the normal level and, despite the very weak A activity of K.S's red cells, the A transferase level was about 50% of that found in the serum of group A individuals with normal strength of A antigen. Moreover, the A transferase on the basis of its pH optimum, Km values for donor and acceptor substrates, activation by divalent cations, isoelectric focusing profile and capacity to convert O to A-active cells, was characterized as the product of an A1 gene. A family study showed that K.S's wife is group A2 and that they have two sons, one group A2 and the other group B. The group B son is assumed to have inherited a B gene from the propositus but the level of B transferase in the son's serum is three times as high as that...Continue Reading

References

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Citations

Jan 1, 1983·Human Genetics·E SchoenleE R Froesch
Jan 16, 1998·The New England Journal of Medicine·L StrainD T Bonthron
May 17, 2002·The New England Journal of Medicine·Neng YuEdmond J Yunis
Jun 1, 1982·Journal of Immunogenetics·J BadetC Salmon
Jun 3, 2008·Forensic Science International : Synergy·Sylvain GiraudMartial Saugy
Sep 13, 2011·American Journal of Medical Genetics. Part a·Paul A JamesFiona Norris
Oct 10, 2006·Clinical Genetics·V MalanC Turleau
Nov 2, 2006·Transfusion·Mira MosebachMarcell U Heim
Apr 22, 2008·Transfusion·Nicole L DraperKaaron Benson
Jan 1, 1983·Vox Sanguinis·P Tippett
Mar 1, 1994·American Journal of Medical Genetics·T C Falik-BorensteinR R Schreck
Aug 31, 2010·American Journal of Medical Genetics. Part a·Johanna WinbergAnn Nordgren
Feb 14, 2006·American Journal of Medical Genetics. Part a·Sylvie BourthoumieuCatherine Yardin
Jul 6, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·N CheaA Tarantola
May 2, 2018·Journal of Assisted Reproduction and Genetics·R J LaursenE M Vestergaard
Dec 12, 2018·Andrologia·Eun Jung ChoiYoung Jin Lee

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