PMID: 6785361Apr 1, 1981Paper

A human dispermic chimaera first suspected from analyses of the blood group gene-specified glycosyltransferases

Journal of Immunogenetics
W M WatkinsW Loeb


The red cells of a normal male blood donor, K.S., were first grouped as B but he was found to lack anti-A in his serum. Closer investigation revealed that his red cells had very weak A activity, demonstrable only by absorption and elution of anti-A. He is a non-secretor of ABH and a secretor of Lea. Blood group A-, B and H-gene specified glycosyltransferases were detected in his serum. In contrast to the finding of a B antigen of normal strength on his red cells, the B transferase in his serum was only about 30% of the normal level and, despite the very weak A activity of K.S's red cells, the A transferase level was about 50% of that found in the serum of group A individuals with normal strength of A antigen. Moreover, the A transferase on the basis of its pH optimum, Km values for donor and acceptor substrates, activation by divalent cations, isoelectric focusing profile and capacity to convert O to A-active cells, was characterized as the product of an A1 gene. A family study showed that K.S's wife is group A2 and that they have two sons, one group A2 and the other group B. The group B son is assumed to have inherited a B gene from the propositus but the level of B transferase in the son's serum is three times as high as that...Continue Reading


Jun 1, 1976·Journal of Immunogenetics·J P CartronC Salmon
Feb 1, 1978·Revue française de transfusion et immuno-hématologie·W M Watkins
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Jan 1, 1969·British Medical Bulletin·C E Ford
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Jan 1, 1957·Vox Sanguinis·W WEINERR R RACE
Oct 10, 1964·Nature·I A UCHIDAM RAY

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