A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium

The American Journal of Physiology
G J PelletierB P Hackett

Abstract

Members of the forkhead/winged-helix transcription factor family play crucial roles during vertebrate development. A human hepatocyte nuclear factor/forkhead homolog (HFH)-4 cDNA encoding a 421-amino acid protein was isolated from a human fetal lung cDNA library. By Southern blot analysis of human-rodent somatic cell hybrid genomic DNA, the human HFH-4 gene localizes to chromosome 17q23-qter. This is the locus of another forkhead/winged-helix gene, the interleukin enhancer binding factor gene. RNA blot analysis revealed a 2.5-kilobase human HFH-4 transcript in fetal lung, kidney, and brain as well as in adult reproductive tissues, lung, and brain. By in situ hybridization, HFH-4 expression is associated with differentiation of the proximal pulmonary epithelium, starting during the pseudoglandular stage of human lung development. During human renal morphogenesis, HFH-4 is expressed in the developing epithelial cells of the ureteric duct, glomerulus, and epithelial vesicles. The unique pattern of HFH-4 expression during human fetal development suggests a role for this forkhead/winged-helix factor during pulmonary and renal epithelial development.

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Citations

Jun 2, 2007·American Journal of Respiratory Cell and Molecular Biology·Brigitte N GompertsBrian P Hackett
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R H CostaL Lim
Dec 6, 2003·American Journal of Respiratory Cell and Molecular Biology·Aaron HamvasPhilip L Ballard
Jul 10, 2004·American Journal of Respiratory Cell and Molecular Biology·Hajime YoshisueJohn W Holloway
Oct 21, 2020·Biochemical Society Transactions·Eamon Dubaissi
Mar 5, 2004·Journal of Cell Science·Brigitte N GompertsBrian P Hackett
Dec 22, 2006·Journal of Cell Science·Helen R DaweKeith Gull

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