PMID: 9526070Apr 4, 1998Paper

A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system

Brain Research. Molecular Brain Research
P J DonohueJ Battey

Abstract

The mammalian bombesin (Bn)-like neuropeptide receptors gastrin-releasing peptide receptor (GRP-R) and neuromedin B receptor (NMB-R) transduce a variety of physiological signals that regulate secretion, growth, muscle contraction, chemotaxis and neuromodulation. We have used reverse transcription-polymerase chain reaction (PCR) to isolate a cDNA from human brain mRNA, GPCR/CNS, that encodes a putative G protein-coupled receptor (GPCR) based upon the presence of the paradigmatic seven heptahelical transmembrane domains in its predicted amino acid sequence. Analysis of the deduced protein sequence of GPCR/CNS reveals this putative receptor to be 98% identical to the deduced amino acid sequence of a recently reported gene product and minimally identical (approximately 23%) to both murine GRP-R and human endothelin-B (ET-B) receptor. Our deduced protein sequence differs at 12 positions, scattered throughout the open reading frame, relative to the original sequence. A 3.7 kb GPCR/CNS mRNA species is expressed in vivo in a tissue-specific manner, with highest levels detected in brain and spinal cord, lower levels found in testis, placenta and liver, but no detectable expression observed in any other tissue. Analysis of GPCR/CNS genom...Continue Reading

References

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Citations

May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rebecca C MeyerRandy A Hall
Aug 19, 2014·Brain Research·Rebecca C MeyerRandy A Hall
May 7, 2016·Current Opinion in Rheumatology·Mark Asquith, James T Rosenbaum
Sep 25, 2007·Neuroscience Research·Yuzuru ImaiRyosuke Takahashi
Jul 10, 2009·Behavior Research Methods·Natasha B SchultzDavid A Washburn
Jul 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Myles R McCraryShan P Yu
Apr 13, 2018·Frontiers in Molecular Neuroscience·Wu ZhengJiang-Fan Chen
Jul 9, 2003·Annals of the New York Academy of Sciences·Ryosuke TakahashiYoshikuni Mizuno
Dec 2, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Ryosuke Takahashi
Jul 1, 2020·Genes·Lyndsay R Watkins, Cesare Orlandi
Feb 28, 2021·Translational Neurodegeneration·Xavier MoratóFrancisco Ciruela
Jun 21, 2017·Trends in Pharmacological Sciences·Lina Leinartaité, Per Svenningsson
Dec 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohaddeseh Sadat AlaviAli Roohbakhsh

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