A human genome-wide library of local phylogeny predictions for whole-genome inference problems.

BMC Genomics
Srinath Sridhar, Russell Schwartz

Abstract

Many common inference problems in computational genetics depend on inferring aspects of the evolutionary history of a data set given a set of observed modern sequences. Detailed predictions of the full phylogenies are therefore of value in improving our ability to make further inferences about population history and sources of genetic variation. Making phylogenetic predictions on the scale needed for whole-genome analysis is, however, extremely computationally demanding. In order to facilitate phylogeny-based predictions on a genomic scale, we develop a library of maximum parsimony phylogenies within local regions spanning all autosomal human chromosomes based on Haplotype Map variation data. We demonstrate the utility of this library for population genetic inferences by examining a tree statistic we call 'imperfection,' which measures the reuse of variant sites within a phylogeny. This statistic is significantly predictive of recombination rate, shows additional regional and population-specific conservation, and allows us to identify outlier genes likely to have experienced unusual amounts of variation in recent human history. Recent theoretical advances in algorithms for phylogenetic tree reconstruction have made it possible ...Continue Reading

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Methods Mentioned

BETA
genotyping
GTPase

Software Mentioned

Biomart
Perl
Linux
SigmaPlot
RepeatMasker
Graphviz
Gnuplot
CPLEX
PHASE
Ensemble BioMart

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