PMID: 2114012Jun 25, 1990Paper

A human immunoglobulin kappa orphon without sequence defects may be the product of a pericentric inversion

Nucleic Acids Research
C HuberH G Zachau

Abstract

The VK gene segments that have been transposed from the kappa locus on the short arm of chromosome 2 at 2p11-12 to other chromosomal sites are called orphons. The 18 VK orphons sequenced up to now carry defects and are to be considered pseudogenes. We now describe the VKI gene segment V108 whose sequence is without any defects and which was localized to the long arm of chromosome 2 at 2q12-14 by in situ hybridization. The V108 region may have been transposed from the short to the long arm of chromosome 2 by a pericentric inversion. Possible reasons for the conservation of its sequence are discussed. In spite of its bona fide sequence V108 is considered to be an unlikely candidate for a VK-JK rearrangement and subsequent functional expression.

References

Mar 1, 1990·Biological Chemistry Hoppe-Seyler·F J ZimmerH G Zachau
Apr 3, 1986·Nature·E LötscherH G Zachau
Jan 1, 1986·Human Genetics·M DjalaliA Smith
Jul 11, 1984·Nucleic Acids Research·B StraubingerH G Zachau
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
May 1, 1982·The Journal of Experimental Medicine·O W McBrideP Leder
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S MalcolmT H Rabbitts

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Citations

Dec 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C A SargentN A Affara
Feb 10, 1995·Genomics·K ErmertH G Zachau
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M A RobinsonP Concannon
Jan 1, 1997·International Reviews of Immunology·T J Kipps
Jun 9, 2007·Cancer Genetics and Cytogenetics·Renata WoronieckaPrzemyslaw Janik
May 1, 1997·European Journal of Immunology·J P FrippiatM P Lefranc
Apr 1, 1994·European Journal of Immunology·J P CoxG Winter

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