A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors

Cell Host & Microbe
Heng ZhangIan A Wilson

Abstract

Recent avian-origin H10N8 influenza A viruses that have infected humans pose a potential pandemic threat. Alterations in the viral surface glycoprotein, hemagglutinin (HA), typically are required for influenza A viruses to cross the species barrier for adaptation to a new host, but whether H10N8 contains adaptations supporting human infection remains incompletely understood. We investigated whether H10N8 HA can bind human receptors. Sialoside glycan microarray analysis showed that the H10 HA retains a strong preference for avian receptor analogs and negligible binding to human receptor analogs. Crystal structures of H10 HA with avian and human receptor analogs revealed the basis for preferential recognition of avian-like receptors. Furthermore, introduction of mutations into the H10 receptor-binding site (RBS) known to convert other HA subtypes from avian to human receptor specificity failed to switch preference to human receptors. Collectively, these findings suggest that the current H10N8 human isolates are poorly adapted for efficient human-to-human transmission.

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Citations

Mar 15, 2015·Cell Host & Microbe·Mathilde Richard, Ron A M Fouchier
Mar 15, 2015·Cell Host & Microbe·Netanel TzarumIan A Wilson
Jun 17, 2016·Annual Review of Analytical Chemistry·Andreas Geissner, Peter H Seeberger
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May 18, 2016·Experimental Biology and Medicine·Mia L HuangKamil Godula
Feb 6, 2018·Nature Structural & Molecular Biology·Nicholas C Wu, Ian A Wilson
Apr 14, 2017·Journal of Virology·Netanel TzarumIan A Wilson
Jul 12, 2017·EMBO Molecular Medicine·Robert P de VriesJames C Paulson
Dec 14, 2017·International Journal of Molecular Sciences·Khristine Kaith S LlorenMin-Suk Song
Jul 12, 2018·Scientific Reports·Ericka KirkpatrickFlorian Krammer
Jun 16, 2017·PLoS Pathogens·Robert P de VriesJames C Paulson
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Apr 14, 2017·Cell Reports·Netanel TzarumIan A Wilson
Nov 30, 2016·ACS Omega·Susan Yu TsengChi-Huey Wong
Oct 9, 2020·Cell Host & Microbe·Sander HerfstRon A M Fouchier

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