A Human Long Non-coding RNA LncATV Promotes Virus Replication Through Restricting RIG-I-Mediated Innate Immunity

Frontiers in Immunology
Jingjing FanWei Yang

Abstract

Pattern recognition receptors sense pathogen components and initiate the host antiviral innate immune response, such as inducing interferons (IFNs). Long non-coding RNAs (lncRNAs) are emerging regulators of multiple biological processes. However, their role in antiviral response, especially through regulating the human innate immune, is largely unexplored. Here we characterized that lncATV, a human specific lncRNA, was up-regulated upon type I/III IFN stimulations and virus infection. LncATV was cytoplasmic localized and relatively high expressed in human monocytes, erythroleukemia cells and hepatoma cells. Notably, lncATV knockdown significantly inhibited the replication of multiple RNA viruses, such as hepatitis C virus, Zika virus, Newcastle disease virus, and Sendai virus. Mechanistically, RIG-I antiviral signaling and IFN effective pathway were enhanced when lncATV expression was knocked down but inhibited by overexpressed lncATV. RNA immunoprecipitation results demonstrated an association between LncATV and RIG-I. Collectively, our findings reveal the functional role of a novel human specific lncATV as a regulatory lncRNA restricting virus associated innate immune response.

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Citations

Aug 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jorn E StokAnnemarthe G van der Veen
Mar 24, 2020·Nature Reviews. Immunology·Jan Rehwinkel, Michaela U Gack
Sep 10, 2020·International Journal of Molecular Sciences·Beatriz SuarezPuri Fortes
Aug 6, 2019·Frontiers in Immunology·Morgan Brisse, Hinh Ly
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Nov 4, 2020·RNA Biology·Katharina Walther, Leon N Schulte
Jan 5, 2021·The Journal of Clinical Investigation·Manish MuhuriGuangping Gao
Jun 26, 2020·Seminars in Cell & Developmental Biology·Tim Vierbuchen, Katherine A Fitzgerald
Jan 20, 2021·Cellular & Molecular Immunology·Koji OnomotoMitsutoshi Yoneyama
Jan 24, 2021·Seminars in Cancer Biology·Mohammad Imran KhanHasan Mukhtar
Jun 3, 2021·Cancers·Lidia BorkiewiczIlona Telejko
Jul 13, 2021·Reviews in Medical Virology·Mina Mobini KeshehSomayeh Shokri
Sep 17, 2021·Essays in Biochemistry·Thomaz Lüscher-DiasHelder I Nakaya

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Methods Mentioned

BETA
pull-down
transfection
immunoprecipitation

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