Sep 1, 1989

A human monoclonal autoantibody isolated from a patient with infectious mononucleosis reactive with both self antigens and Epstein-Barr virus nuclear antigen (EBNA)

Immunology Letters
C GarzelliG Falcone

Abstract

In order to investigate the mechanism(s) by which Epstein-Barr virus (EBV) induces the outcome of autoantibodies during infectious mononucleosis (IM), a human IgM (k) monoclonal antibody to cytoskeletal filaments of epithelial cells has been prepared by EBV transformation of peripheral blood B lymphocytes obtained from a patient with IM. The antibody was also found to react with smooth muscle of frozen sections of human stomach tissue by immunofluorescence, and with the Epstein-Barr nuclear antigen (EBNA) by an enzyme-linked immunosorbent assay. These findings demonstrate at the clonal level the epitope homology between host's cell antigens and EBV-encoded nuclear antigen, which might have relevance in EBV-induced autoimmunity.

Mentioned in this Paper

Monoclonal Antibodies
Immunofluorescence Assay
Autoantibodies
Infectious Mononucleosis
Peripheral Blood
Squamous Transitional Epithelial Cell Count
Antigenic Specificity
Antibody Test; Epstein-Barr (EB) Virus, Nuclear Antigen (EBNA)
Smooth Muscle
Mesothelium

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