A human protective protein gene partially overlaps the gene encoding phospholipid transfer protein on the complementary strand of DNA

Biochemical and Biophysical Research Communications
M ShimmotoH Sakuraba

Abstract

The entire human protective protein gene has been cloned, and structural analysis revealed that the gene spans 7.5kb and comprises 15 exons. Furthermore, it partially overlaps on the opposite strand with the gene encoding phospholipid transfer protein. This region of DNA on chromosome 20 appears to encode two distinct mRNAs expressing defined functional products, and the mRNAs overlap by 58 nucleotides at their 3'-untranslated ends.

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