PMID: 8990175Jan 7, 1997Paper

A human protein related to yeast Cdc6p

Proceedings of the National Academy of Sciences of the United States of America
R S WilliamsB Stillman

Abstract

The unstable proteins Cdc6p and cdc18+ are essential and rate limiting for the initiation of DNA replication in Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively, and also participate in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. We have identified Xenopus and human proteins closely related to Cdc6p/cdc18. The human protein, p62(cdc6), is encoded on chromosome 17q21.3 and includes putative cyclin-dependent kinase phosphorylation sites, destruction boxes, a nucleotide binding/ATPase domain, and a potential leucine zipper. Expression of p62(cdc6) mRNA and protein is suppressed in human diploid fibroblasts made quiescent by serum starvation, and peaks as cells reenter the cell cycle and replicate DNA following serum stimulation. Conservation of structure among proteins involved in initiation suggests that fundamental features of replication complexes are maintained in all eukaryotes.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E Hogan, D Koshland
May 14, 1992·Nature·J F Diffley, J H Cocker
Jan 1, 1990·Methods in Enzymology·F W StudierJ W Dubendorff
Dec 23, 1988·Nucleic Acids Research·J LisziewiczH Küntzel
May 5, 1986·Journal of Molecular Biology·F W Studier, B A Moffatt
Dec 8, 1995·Science·K A GavinB Stillman
Dec 8, 1995·Science·M GossenM R Botchan
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·H Rao, B Stillman
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·T J KellyS L Forsburg
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·K OhtaniJ R Nevins
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·M Muzi-Falconi, T J Kelly
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M Muzi FalconiT J Kelly

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Citations

Mar 5, 2003·Journal of Molecular Biology·Margot KneisslFriedrich Grummt
Jun 1, 1997·Current Opinion in Cell Biology·P V Jallepalli, T J Kelly
Feb 19, 2002·Trends in Cell Biology·J Julian Blow, Ben Hodgson
Apr 4, 2009·Nature Structural & Molecular Biology·Roberta PaolinelliMauro Giacca
Feb 16, 2002·European Journal of Biochemistry·Esther BiermannRolf Knippers
Jun 13, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hideo Nishitani, Zoi Lygerou
Apr 10, 2008·The Journal of Biological Chemistry·Anthony J DavisMarc C Mumby
Apr 16, 2002·Molecular Biology of the Cell·Natalya S FrolovaThomas R Coleman
Oct 8, 1999·Molecular Biology of the Cell·S ElsasserJ L Campbell
Aug 6, 1999·Molecular Biology of the Cell·U HerbigE Fanning
Oct 1, 2003·Molecular Biology of the Cell·Hyungshin YimSeung Ki Lee
Dec 1, 2007·Carcinogenesis·Luis R Borlado, Juan Méndez
Jun 10, 1998·The EMBO Journal·G AbdurashidovaA Falaschi
Nov 14, 1997·Genes & Development·P V JallepalliT J Kelly
Aug 5, 2004·European Journal of Biochemistry·Georgia XouriStavros Taraviras
Jan 1, 1997·Annual Review of Cell and Developmental Biology·A Dutta, S P Bell
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·W N RomK M Tchou-Wong
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·W Jiang, T Hunter
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z YanR S Williams
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·W JiangT Hunter
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·G H WilliamsN Coleman
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·M WeinreichB Stillman
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·J TianW J Lennarz
Feb 13, 2001·Current Opinion in Genetics & Development·K Labib, J F Diffley
Jan 6, 2010·The Journal of Cell Biology·Keman ZhangMarian L Harter
Mar 21, 2001·The Journal of Cell Biology·L FurstenthalP K Jackson
Jul 28, 2004·Molecular Reproduction and Development·Jean-Marc LemaîtreMarcel Méchali
Jan 28, 2006·EMBO Reports·Eric LauWei Jiang
Jul 5, 2007·The FEBS Journal·S PollokF Grosse
Oct 12, 2004·Biochemical and Biophysical Research Communications·Megumi KuritaMasaaki Matsuoka

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