A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde.

Acta Dermato-venereologica
Chris R HøjlandParisa Gazerani

Abstract

The thermoreceptive transient receptor potential ankyrin 1 (TRPA1) is important in the transmission of itch, and its agonist trans-cinnamaldehyde has occasionally been reported to be a pruritogen in humans. However, no studies have accurately quantified the capabilities of trans-cinnamaldehyde to induce itch and related dysesthetic sensations. The present study examined alterations in somatosensory and vasomotor parameters in response to topical trans-cinnamaldehyde 5% and vehicle (ethanol) in 24 healthy subjects. During the study the following parameters were recorded: itch area and intensity, hyperknesis, alloknesis, neurogenic flare, skin blood flow and temperature. Trans-cinnamaldehyde evoked moderate itch sensation, flare, hyperknesis and alloknesis (p < 0.001). Blood flow and skin temperature were elevated in the area of trans-cinnamaldehyde application (p < 0.001). Significant positive correlations were found between blood flow and skin temperature, itch area and blood flow, and itch area and skin temperature. Topical trans-cinnamaldehyde proved feasible as a human itch model with applicability in studying itch mechanisms or anti-pruritic drug profiling.

Citations

Nov 2, 2019·Physiological Reviews·Karel TalaveraBernd Nilius
May 2, 2018·Seminars in Immunopathology·Jae Eun Choi, Anna Di Nardo
Mar 9, 2021·Frontiers in Medicine·Aylin RuppensteinUlrike Raap
Jul 25, 2021·International Journal of Molecular Sciences·Qiaojuan ZhangYong Chen

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