A hybrid clinical-research depth electrode for acute and chronic in vivo microelectrode recording of human brain neurons. Technical note

Journal of Neurosurgery
M A HowardH E Bakken

Abstract

For several decades, important scientific information has been gained from in vivo microelectrode recordings of individual human cerebral cortical neurons in patients with epilepsy. The experimental methods used, however, are technically complex and require a highly skilled intraoperative team. There are also significant experimental time limitations, as well as constraints on the type of behavioral tests conducted, and the brain regions that may be safely studied. In this report, a new method is described for obtaining in vivo microelectrode recordings using a hybrid depth electrode (HDE). High-impedance research recording contacts are interspersed between low-impedance clinical electroencephalographic (EEG) contacts along the HDE shaft. The HDE has the same external physical properties as a standard clinical depth electrode (DE). Following preclinical laboratory testing, 15 HDEs were used in the evaluation of six patients with medically refractory epilepsy. High-quality EEG recordings were obtained in all cases (two acute intraoperative, four from the chronic epilepsy monitoring unit). Action potentials from individual neurons were successfully recorded during all experimental sessions; however, the chronic preparations were ...Continue Reading

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Citations

Dec 29, 1998·Behavioural Brain Research·Y G AbdullaevK V Melnichuk
Jun 1, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·N P Bechtereva, Y G Abdullaev
Jul 22, 1998·Progress in Neurobiology·P Heiduschka, S Thanos
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hiroyuki OyaMatthew A Howard
Mar 15, 2006·IEEE Transactions on Bio-medical Engineering·Francisco M Martínez SantiestebanDavid J Anderson
Aug 14, 2009·Journal of Neurophysiology·John F BruggeMatthew A Howard
Nov 5, 2005·Journal of Cognitive Neuroscience·Hiroto KawasakiMatthew Howard
Apr 2, 2011·Journal of Cognitive Neuroscience·Sukhbinder KumarTimothy D Griffiths
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rick L JenisonMatthew A Howard
Aug 12, 2009·Journal of Neurosurgery·Chandan G ReddyMatthew A Howard
Apr 28, 2001·The Journal of the Acoustical Society of America·J L Wunderlich, B K Cone-Wesson
Sep 29, 2011·Annual Review of Psychology·Roy Mukamel, Itzhak Fried
Jan 22, 2008·Hearing Research·John F BruggeMatthew A Howard
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Jan 1, 2013·Trends in psychiatry and psychotherapy·André RutzMelissa Lamar
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Nov 24, 2020·Neuropsychologia·Sukhbinder KumarTimothy D Griffiths
Oct 17, 2020·Cerebral Cortex·Kirill V NourskiMatthew A Howard

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