A hybrid thermo-sensitive chitosan gel for sustained release of Meloxicam

Journal of Biomaterials Science. Polymer Edition
Ye WangWenquan Liang

Abstract

The purpose of this work was to develop a multi-phase gel system for sustained release drug delivery. A thermo-sensitive hydrogel composed of chitosan and glycerol was prepared, and then an o/w emulsion was introduced to the thermo-sensitive gel in order to modulate the gelation behavior. Meloxicam was chosen as a model drug in this study and its release profile was investigated. This study revealed that the factors such as pH, chitosan molecular mass and glycerol concentration could significantly influence the gel formation. Chitosan with a molecular mass of 950 kDa and glycerol proportion ranging from 30 to 60% can form a pH-dependent thermo-sensitive gel system. Both the chitosan-glycerol gel and chitosan-glycerol-emulsion gel systems were applied in delivering drugs. The drug release from the two gels was both in Higuchi mode. Higuchi moduli were 3.04 x 10(-3) mg x h((1/2)) in the chitosan-glycerol-emulsion gel and 1.28 mg x h((1/2)) in the chitosan- glycerol gel. The former was significantly slower in sustained release. The in vivo investigation on the chitosan-glycerol gel indicated that the gel may be useful in sustained drug release in situ. Thermosensitive hydrogels composed of chitosan and glycerol were well formed an...Continue Reading

References

Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·E Ruel-GariépyJ-C Leroux
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Omathanu Pillai, Ramesh Panchagnula
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-GariépyJean-Christophe Leroux
Apr 18, 2006·International Journal of Pharmaceutics·Jie WuGuang-Hui Ma
Jun 10, 2006·Advanced Drug Delivery Reviews·Jiyoung M Dang, Kam W Leong
Oct 10, 2006·Biomacromolecules·Hui YanAline F Miller
Dec 5, 2006·Journal of Materials Science. Materials in Medicine·Wei Wang
Mar 27, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tommasina CovielloFranco Alhaique

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Citations

Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad YarIhtesham Ur Rehman
Mar 27, 2013·Pharmaceutical Development and Technology·Rawia M KhalilMona Basha
Oct 29, 2013·Journal of Biomaterials Science. Polymer Edition·Guoqiang JiangFuxin Ding
Mar 10, 2016·Drug Delivery·Jianmin Chen, Yunhua Gao
Nov 12, 2020·Materials·Rayssa de Sousa VictorRomualdo Rodrigues Menezes

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