A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

Organic & Biomolecular Chemistry
William DohertyJoanna F McGouran

Abstract

Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.

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Citations

Nov 26, 2020·Current Protocols in Nucleic Acid Chemistry·Guillaume ClavéMichael Smietana
Oct 10, 2020·European Journal of Medicinal Chemistry·Jan ChasákLucie Brulíková
Jan 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva-Maria Dürr, Joanna F McGouran
Feb 23, 2020·Organic Letters·Guillaume ClavéMichael Smietana
Apr 20, 2021·ACS Omega·Beverlee BuzonMurray Junop

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Methods Mentioned

BETA
electrophoresis
column chromatography
NMR

Software Mentioned

Prism
GraphPad

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