PMID: 11309785Apr 20, 2001Paper

A hydroxyapatite coating covalently linked onto a silicone implant material

Journal of Biomedical Materials Research
Tsutomu FuruzonoJ Tanaka

Abstract

A novel composite consisting of hydroxyapatite (HAp) microparticles covalently coupled onto a silicone sheet was developed. Initially, an acrylic acid (AAc) -grafted silicone sheet with a 16.7 microg/cm(2) surface graft density was prepared by corona-discharge treatment. The surface of sintered, spherical, carbonated HAp particles with an average diameter of 2.0 microm was subsequently modified with amino groups. The amino group surface density of the HAp particles was calculated to be approximately one amino molecule per 1.0 nm(2) of particle surface area. These samples were characterized with Fourier transform infrared spectrometry and X-ray photoelectron spectroscopy. After the formation of ammonium ionic bonds between both samples under aqueous conditions, they were reacted at 180 degrees C for 6 h in vacuo to form covalent bonds through a solid-phase condensation. The HAp particles were coupled to the AAc-grafted silicone surface by a covalent linkage. Further improvements in the adhesive and bioactive properties of the HAp-coated silicone material are expected.

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Citations

Aug 13, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroshi YanagidaTsutomu Furuzono
May 8, 2007·Journal of Materials Science. Materials in Medicine·Yoshiro YokoyamaAtsuo Ito
May 8, 2007·Journal of Materials Science. Materials in Medicine·Hirotaka MutsuzakiNaoyuki Ochiai
Dec 5, 2002·Journal of Biomaterials Science. Polymer Edition·Limin SuKarlis A Gross
Aug 12, 2009·Journal of Bioscience and Bioengineering·Hiroshi YanagidaKazuo Takakuda
Jul 26, 2008·Journal of Biomedical Materials Research. Part a·A SchuesseleA Goepferich
Feb 21, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hirotaka MutsuzakiNaoyuki Ochiai
Dec 29, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yoshiro YokoyamaAtsuo Ito
Aug 11, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Koji OsumiYuko Kitagawa
Mar 12, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·F ZhaoK D Yao
Jul 27, 2005·Journal of Biomedical Materials Research. Part a·Ayako OyaneAtsuo Ito
Apr 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Z Y LiK D K Luk
Dec 4, 2004·Journal of Biomedical Materials Research. Part a·Ayako OyaneAtsuo Ito
Aug 18, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Hayata MaedaTsutomu Furuzono
Jan 14, 2019·ACS Biomaterials Science & Engineering·Alicja Kosik-KoziołCedryck Vaquette
Nov 13, 2021·Biomaterials Science·Shreyasi MajumdarSairam Krishnamurthy

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