PMID: 9440321Jan 24, 1998Paper

A hydroxypyridinone (CP94) enhances protoporphyrin IX formation in 5-aminolaevulinic acid treated cells

Journal of Photochemistry and Photobiology. B, Biology
O BechAlexander J MacRobert

Abstract

Different cell lines were given photodynamic treatment with 5-aminolaevulinic acid (ALA) and light. In addition, the iron chelator 1,2-diethyl-3-hydroxypyridin-4-one (CP94) was used. The porphyrin species produced was spectrofluorimetrically identified as protoporphyrin IX. All the cell lines responded to treatment, including a multidrug resistance gene expressing bladder cancer line and, to a lesser degree, cells derived from untransformed human skin fibroblasts. CP94 enhanced both porphyrin fluorescence, total porphyrin content and photosensitivity of the cells. CCD fluorescence microscopy showed a granular extranuclear porphyrin fluorescence distribution for all the cell lines involved, but the untransformed cells showed a distribution pattern different from the ones seen in the other cells.

References

Jul 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·J C Kennedy, R H Pottier
Mar 1, 1992·Photochemistry and Photobiology·D Kessel, C Erickson
Jul 11, 1990·The Journal of Urology·J W FloydG R Prout
Dec 4, 1987·Journal of Immunological Methods·E N Dotsika, C J Sanderson
May 1, 1982·Seminars in Liver Disease·G H Elder
Jan 1, 1995·Lasers in Surgery and Medicine·A M FisherC J Gomer
Nov 1, 1995·Photochemistry and Photobiology·D KesselC K Chang

❮ Previous
Next ❯

Citations

Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Asta JuzenieneJohan Moan
Jun 12, 1999·Journal of Photochemistry and Photobiology. B, Biology·M G StrakhovskayaA B Rubin
Mar 1, 2006·Photodiagnosis and Photodynamic Therapy·Aurelie FurigaThierry Patrice
Oct 31, 2015·International Journal of Molecular Sciences·Xue YangBin Chen
Mar 18, 2006·Photochemistry and Photobiology·Nicolas FotinosNorbert Lange
Mar 21, 2006·The International Journal of Biochemistry & Cell Biology·Sinan BattahAlexander J MacRobert
Apr 27, 1999·The Journal of Pharmacy and Pharmacology·H Cable, J B Lloyd
Jun 1, 2007·Photodiagnosis and Photodynamic Therapy·Asta Juzeniene, Johan Moan
Apr 1, 2017·Journal of Medicinal Chemistry·Sinan BattahTao Zhou
Oct 18, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Kunal M Tewari, Ian M Eggleston
Nov 30, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Asta JuzenieneJohan Moan
Jan 3, 2020·Photochemistry and Photobiology·Aaron J SorrinImran Rizvi
Jun 21, 2008·Molecular Cancer Therapeutics·Ludovic BourréAlexander J MacRobert
Jun 6, 2014·ACS Medicinal Chemistry Letters·Anna Mrozek-WilczkiewiczJaroslaw Polanski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.