PMID: 7525891Jul 1, 1994Paper

A hyperpolarization-activated cation conductance in lobster olfactory receptor neurons

Journal of Neurophysiology
F S Corotto, W C Michel

Abstract

1. The current underlying inward rectification in lobster olfactory receptor neurons was investigated with the use of whole-cell patch-clamp techniques. Inward rectification could most likely result from an inwardly rectifying potassium conductance or a hyperpolarization-activated cation conductance. To distinguish between these possibilities, the current underlying inward rectification was examined with respect to its sensitivity to extracellular Cs+ and Ba2+, time course of activation, and reversal potential. 2. In current clamp, injection of negative current led to a hyperpolarization followed by a partial return (sag) toward the initial holding potential. The rate and magnitude of the sag depended on the magnitude of the hyperpolarizing current with larger currents leading to larger, faster depolarizing sags. In voltage clamp, hyperpolarizing steps elicited a slowly activating, noninactivating inward current clamp. Both the sag and the slow inward current were blocked reversibly by extracellular application of 5 mM CsCl but were unaffected by 2 mM BaCl2. 3. The rate of inward current activation was best approximated by a single exponential function with time constants that were voltage dependent, ranging from 7.8 s at -69 m...Continue Reading

Citations

Apr 23, 2005·The European Journal of Neuroscience·Günter GisselmannHanns Hatt
Sep 24, 1998·Journal of Neurophysiology·F S Corotto, W C Michel
Oct 18, 2003·Insect Biochemistry and Molecular Biology·Günter GisselmannHanns Hatt

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