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A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

MBio

Jul 11, 2019

J Maximilian FelsKartik Chandran

Abstract

Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine receptors, endosomal cysteine proteases...read more

Mentioned in this Paper

Study
United States Food and Drug Administration
Virus
Ebola virus
Ebolavirus
Vaccines
Glycoproteins
West (Direction)
Pharmacologic Substance
Lysosomes
33
6
Paper Details
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© 2020 Meta ULC. All rights reserved

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

MBio

Jul 11, 2019

J Maximilian FelsKartik Chandran

PMID: 31289183

DOI: 10.1128/mbio.01408-19

Abstract

Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine receptors, endosomal cysteine proteases...read more

Mentioned in this Paper

Study
United States Food and Drug Administration
Virus
Ebola virus
Ebolavirus
Vaccines
Glycoproteins
West (Direction)
Pharmacologic Substance
Lysosomes
33
6

Similar Papers Found In These Feeds

Viral Hemorrhagic Fevers

Viral Hemorrhagic Fevers caused by ebola, marburg and lassa viruses often manifest as multiple organ dysfunction and hemorrhagic shock with high mortality. Discover the latest research on Viral Hemorrhagic Fevers here.

Proteostasis

Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.

Related Papers

MBio

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

MBioFebruary 11, 2016
Jennifer S SpenceKartik Chandran
Journal of Virology

Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry

Journal of VirologyMarch 6, 2015
Aileen O'HearnLijun Rong
Paper Details
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