A hyperstructure approach to mitochondria

Molecular Microbiology
Mirella TrineiVic Norris

Abstract

Several questions in our understanding of mitochondria are unanswered. These include how the ratio of mitochondrial (mt)DNA to mitochondria is maintained, how the accumulation of defective, rapidly replicating mitochondrial DNA is avoided, how the ratio of mitochondria to cells is adjusted to fit cellular needs, and why any proteins are synthesized in mitochondria rather than simply imported. In bacteria, large hyperstructures or assemblies of proteins, mRNA, lipids and ions have been proposed to constitute a level of organization intermediate between macromolecules and whole cells. Here, we suggest how the concept of hyperstructures together with other concepts developed for bacteria such as transcriptional sensing and spontaneous segregation may provide answers to mitochondrial problems. In doing this, we show how the problem of the very existence of mtDNA brings its own solution.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W M BrownA C Wilson
Jan 1, 1989·Annual Review of Microbiology·W Firshein
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Liu, J C Wang
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D M Haverstick, M Glaser
Jan 1, 1974·Journal of Theoretical Biology·C W Dingman
Jun 1, 1995·Trends in Genetics : TIG·T PreissR N Lightowlers
Dec 13, 1996·The Journal of Biological Chemistry·G Schatz
Mar 1, 1997·Molecular Microbiology·A Eliasson, K Nordström
Jan 1, 1997·Annual Review of Biochemistry·G S Shadel, D A Clayton
Aug 1, 1997·Scientific American·D C Wallace
Mar 7, 1998·The Journal of Biological Chemistry·R A SchultzR S Williams
Aug 14, 1998·Molecular Microbiology·B Müller-Hill
Nov 7, 1998·The Journal of Biological Chemistry·D Y Lee, D A Clayton
Jan 19, 1999·Annual Review of Cell and Developmental Biology·G J Hermann, J M Shaw
Mar 17, 1999·Biochimica Et Biophysica Acta·J W Taanman
Mar 20, 1999·Biochemical and Biophysical Research Communications·T OhsatoD Kang
Jun 26, 1999·Molecular Microbiology·I Fishov, C L Woldringh
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·L S JouavilleR Rizzuto
Dec 11, 1999·Nature·L H HartwellA W Murray
Feb 17, 2000·The EMBO Journal·P J LewisJ Errington
Feb 26, 2000·Science·P L BeechG I McFadden
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·D SegréD Lancet
May 20, 2000·Annals of the New York Academy of Sciences·J L Lemke

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Citations

Nov 30, 2012·Archaea : an International Microbiological Journal·Simona LobassoAngela Corcelli
Apr 17, 2010·Journal of Biomedicine & Biotechnology·Paulien SmitsLambert van den Heuvel
Dec 9, 2014·Plant Signaling & Behavior·Vic NorrisMichel Thellier
Apr 22, 2010·Journal of the American Chemical Society·Michael J MoehlenbrockShelley D Minteer

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