PMID: 8971016Dec 1, 1996Paper

A hypervariable region in VP1 of chicken infectious anemia virus mediates rate of spread and cell tropism in tissue culture

Journal of Virology
R W RenshawK A Schat

Abstract

Chicken infectious anemia virus (CIAV) is a unique infectious agent with an amino acid composition that has been found to be remarkably conserved even in isolates from different parts of the world. We have characterized field isolates of CIAV which vary significantly in terms of their abilities to replicate in culture, demonstrating a biological difference between isolates. Two sublines of MDCC-MSB1 cells that differ in their abilities to support CIAV were identified. In the MSB1(S) subline the CIA-1 isolate of CIAV was found to be less cytopathogenic than the prototype Cux-1(C) isolate; the MSB1(L) subline, which supports Cux-1(C) replication, was found to be nonpermissive for CIA-1. Alignments of the VP1 sequences of previously examined isolates with those of the field isolates CIA-1 and L-028 and the culture-adapted ConnB isolate revealed a previously unreported hypervariable region spanning amino acid positions 139 to 151. Chimeras of Cux-1(C) and CIA-1 were constructed to examine the potential for this region to affect cytopathogenicity. Transfer of a 316-bp region of Cux-1(C) open reading frame 1 into CIA-1 produced a virus with a cytopathogenic profile typical of Cux-1(C), indicating that one or both of the amino acid di...Continue Reading

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Citations

Jan 9, 2015·The Journal of General Virology·Dai Q TrinhKunitoshi Imai
Oct 11, 2014·Advances in Virology·Mohammed AboElkhairAbd Elnaby Y Metwally
Dec 10, 2016·Virus Genes·Amir KaffashiAbdelhamed Shoushtari
Jun 26, 2007·Avian Pathology : Journal of the W.V.P.A·Daniel ToddM S McNulty
Aug 26, 2011·Intervirology·Yantao WuSongshu Meng
Feb 15, 2005·Journal of Virology·Myrna M MillerKarel A Schat
Jul 19, 2000·The Journal of General Virology·C J CardonaK A Schat
Oct 7, 2000·Australian Veterinary Journal·H K BrownK Brown
Aug 5, 2010·The Journal of Veterinary Medical Science·Mohie HaridyKosuke Okada
Apr 28, 2007·Avian Diseases·Vicky L van SantenFrederic J Hoerr
Apr 2, 2014·BioMed Research International·Xinheng ZhangQingmei Xie
Aug 13, 2005·Archives of Virology·M F DucatezC P Muller
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·I K MushahwarS M Dexai
Jan 11, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Haitham M AmerAusama A Yousef
Jun 23, 2006·Virus Genes·Simone SimionattoCláudio Wageck Canal
Nov 2, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·S M SreekalaP N Dwivedi
Jun 15, 2019·Avian Pathology : Journal of the W.V.P.A·Maude PaulyClaude P Muller
Jul 19, 2017·Annual Review of Virology·L M Shulman, I Davidson
Mar 28, 2017·Frontiers in Microbiology·Yang LiPeng Zhao
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Giulia QuagliaCaterina Lupini
May 1, 2021·Avian Pathology : Journal of the W.V.P.A·Claudia TecheraRuben Pérez

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