A hypothesis about the relationship of myelin-associated glycoprotein's function in myelinated axons to its capacity to inhibit neurite outgrowth.

Neurochemical Research
R H Quarles

Abstract

The myelin-associated glycoprotein (MAG) is selectively localized in periaxonal Schwann cell and oligodendroglial membranes of myelin sheaths suggesting that it functions in glia-axon interactions in the PNS and CNS, and this is supported by much experimental evidence. In addition, MAG is now well known as one of several white matter inhibitors of neurite outgrowth in vitro and axonal regeneration in vivo, and this latter area of research has provided a substantial amount of information about neuronal receptors or receptor complexes for MAG. This article makes the hypothesis that the capacity of MAG to inhibit outgrowth of immature developing or regenerating neurites is an aberration of its normal physiological function to promote the maturation, maintenance, and survival of myelinated axons. The overview summarizes the literature on the function of MAG in PNS and CNS myelin sheaths and its role as an inhibitor of neurite outgrowth to put this hypothesis into perspective. Additional research is needed to determine if receptors and signaling systems similar to those responsible for MAG inhibition of neurite outgrowth also promote the maturation, maintenance, and survival of myelinated axons as hypothesized here, or if substantia...Continue Reading

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Citations

Jun 25, 2015·The Journal of Biological Chemistry·Tadahiro SuenagaHisashi Arase
Jan 11, 2011·Journal of Neurochemistry·Pablo H H LopezRonald L Schnaar
Nov 9, 2017·The Journal of Cell Biology·Simon Pan, Jonah R Chan
Apr 19, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hirotoshi AkaneMakoto Shibutani
Oct 17, 2009·Experimental Neurology·Sangwoo Shim, Guo-li Ming
Feb 20, 2020·Biochemical and Biophysical Research Communications·Song WangPeifu Tang

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