PMID: 10888648Jul 11, 2000

A hypothesis for DNA viruses as the origin of eukaryotic replication proteins

Journal of Virology
L P Villarreal, V R DeFilippis

Abstract

The eukaryotic replicative DNA polymerases are similar to those of large DNA viruses of eukaryotic and bacterial T4 phages but not to those of eubacteria. We develop and examine the hypothesis that DNA virus replication proteins gave rise to those of eukaryotes during evolution. We chose the DNA polymerase from phycodnavirus (which infects microalgae) as the basis of this analysis, as it represents a virus of a primitive eukaryote. We show that it has significant similarity with replicative DNA polymerases of eukaryotes and certain of their large DNA viruses. Sequence alignment confirms this similarity and establishes the presence of highly conserved domains in the polymerase amino terminus. Subsequent reconstruction of a phylogenetic tree indicates that these algal viral DNA polymerases are near the root of the clade containing all eukaryotic DNA polymerase delta members but that this clade does not contain the polymerases of other DNA viruses. We consider arguments for the polarity of this relationship and present the hypothesis that the replication genes of DNA viruses gave rise to those of eukaryotes and not the reverse direction.

References

Jun 21, 2013·Journal of Molecular Evolution·Kenneth Stedman
Sep 22, 2006·Acta Biotheoretica·Günther Witzany
Mar 10, 2007·Acta Biotheoretica·Günther Witzany
Mar 4, 2010·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·P Forterre
Jan 14, 2010·Virus Genes·Rolf M Flügel
Jan 24, 2002·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·P Forterre
Jun 12, 2003·Research in Microbiology·Dennis H Bamford
Jun 12, 2003·Research in Microbiology·Jonathan FiléeJacqueline Laurent
Oct 2, 2002·Current Opinion in Microbiology·P Forterre
Dec 3, 2005·Nature Reviews. Microbiology·Marilyn J Roossinck
Jul 21, 2004·Nature Reviews. Microbiology·Kay D Bidle, Paul G Falkowski
Apr 24, 2013·Molecular Biology and Evolution·Thomas SchoenfeldBrian P Hedlund
Jul 3, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Harald Brüssow
Apr 3, 2010·Genome Research·Matthieu LegendreJean-Michel Claverie
Jul 27, 2007·Genome Research·Hiroyuki Ogata, Jean-Michel Claverie
Apr 29, 2008·Applied and Environmental Microbiology·Thomas SchoenfeldDavid Mead
Jul 8, 2005·Applied and Environmental Microbiology·Keizo NagasakiShmuel Pietrokovski
Nov 23, 2007·Journal of Virology·Russel H MeintsTae-Jin Choi
Nov 2, 2001·Journal of Virology·L M IyerE V Koonin
Jul 15, 2005·Journal of Virology·Yuanzheng ZhangJames L Van Etten
Aug 6, 2009·Annual Review of Genetics·Jean-Michel Claverie, Chantal Abergel
Jan 22, 2008·BMC Evolutionary Biology·David Moreira, Céline Brochier-Armanet
Aug 18, 2005·Virology Journal·Elodie Ghedin, Jean-Michel Claverie
Feb 15, 2005·Virology Journal·Hiroyuki OgataJean-Michel Claverie
Jan 25, 2008·Virology Journal·Adam MonierHiroyuki Ogata
Jun 22, 2006·Genome Biology·Jean-Michel Claverie
Jul 5, 2008·Genome Biology·Adam MonierHiroyuki Ogata
Feb 24, 2012·PloS One·Timo WulfmeyerTobias Meckel
Dec 19, 2013·Archaea : an International Microbiological Journal·P Forterre
Jun 28, 2014·Nature Communications·Florian MaumusGuillaume Blanc
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·P Forterre
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ming KangJames L Van Etten
Jun 3, 2014·Viruses·Ranjan BoseKay Hamacher
Feb 22, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Danièle GadelleP Forterre
Aug 11, 2010·Trends in Genetics : TIG·Jean-Michel Claverie, Chantal Abergel
Nov 10, 2009·Journal of Molecular Biology·Vasiliy M PetrovJ D Karam
Aug 4, 2009·Research in Microbiology·P Forterre, David Prangishvili
May 22, 2007·Medical Hypotheses·Omar LupiClyde Goodheart

Citations

Jan 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T S WangD Korn
May 1, 1989·Journal of Bacteriology·H Bernstein, C Bernstein
Jan 1, 1983·Annual Review of Biochemistry·J M Bishop
Jan 1, 1984·Annual Review of Genetics·H E Varmus
Nov 3, 1995·The Journal of Biological Chemistry·C C WangJ D Karam
May 5, 1995·Science·B J StaskawiczJ D Jones
Feb 25, 1993·Nucleic Acids Research·D K Braithwaite, J Ito
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·A R Mushegian, E V Koonin
Jan 1, 1995·Virus Genes·E KutterV Mesyanzhinov
Apr 1, 1997·Journal of Bacteriology·D R EdgellW F Doolittle
May 1, 1998·Virus Genes·J Holland, E Domingo
May 1, 1998·Virus Genes·C W Knopf
May 1, 1998·Virus Genes·M Kapp
Dec 16, 1998·Journal of Virology·C L AfonsoD L Rock
Apr 17, 1999·Science·J A LakeM C Rivera

Related Concepts

Polymerase
Phylogeny
DNA Polymerase III
Bacteriophage T4
Microalgae
DNA Replication
Eubacterium
Phycodnaviridae
Chlorella
DNA Viruses

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.