PMID: 6399816Jan 1, 1984Paper

A hypothesis for neural control of the speed of muscle contraction in the mammal

Advances in Biophysics
M Kuno

Abstract

A hypothesis for neural control of the contractile properties of muscle is presented. The hypothesis is based on two assumptions: i) the motoneurons innervating both the fast- and slow-twitch muscles in the mammal possess an identical neurotrophic substance which accelerates the speed of muscle contraction, and ii) slow contractions of the slow-twitch muscle are induced by the low frequency discharges of the innervating motoneurons. The presence of such a trophic substance in the motoneurons is supported by the prolongation of contraction time in both the fast- and slow-twitch muscles following denervation. Furthermore, a given slow-twitch muscle dually reinnervated by the fast and slow muscle nerves contracts at the same speed regardless of which nerve is stimulated, if identical neural activity patterns are chronically imposed upon the two nerves. The presence of effective neural activity patterns in the motoneurons innervating the slow-twitch muscle is supported by an increase in the contraction speed of the slow-twitch muscle following virtual elimination of motoneuron activity by transection of the spinal cord. Under such conditions, contraction time of the fast-twitch muscle remains unchanged. Also, cord transection of ne...Continue Reading

Citations

Aug 10, 2006·European Journal of Applied Physiology·Menotti Midrio
Oct 22, 2013·Journal of Bodywork and Movement Therapies·M Wallden
Jan 13, 2006·Neurourology and Urodynamics·Yavor SemerdzhievBengt Uvelius

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