A hypothesis for the anti-inflammatory and mechanotransduction molecular mechanisms underlying acupuncture tendon healing

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Marcos dos Santos de AlmeidaEdson Rosa Pimentel

Abstract

A previous study demonstrated that acupuncture increases the synthesis and reorganisation of collagen molecules in rat tendons after injury. Clinical studies have shown that acupuncture improves pain and functional activity in patients with tendinopathy. However, the molecular mechanisms underlying these effects are unknown. Recent studies have shown that acupuncture can modulate both anti-inflammatory (AI) and mechanotransduction (MT) molecular pathways. Moreover, the modulation of these pathways can increase type I collagen synthesis, which is the main factor that influences tendon biomechanical properties. Our hypothesis is that acupuncture increases synthesis and subsequent reorganisation of type I collagen during tendon healing by concomitant modulation of the Toll-like receptor-nuclear factor-κB AI pathway, the mitogen-activated protein kinases pathway and the Rho/Rac-F-actin MT pathway. Increased collagen synthesis and reorganisation requires that at least one acupoint is anatomically connected with the site of the injury because of the local tenoblast MT mechanism. Confirmation of this hypothesis will increase the knowledge of acupuncture modulation of the previously mentioned molecular pathways, and such confirmation m...Continue Reading

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Citations

Jul 17, 2015·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Marcos dos Santos AlmeidaEdson Rosa Pimentel
Aug 15, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Fermín Valera-GarridoFrancesc Medina-Mirapeix
Aug 21, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Marcos Dos Santos de AlmeidaEdson Rosa Pimentel
Oct 23, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Motohiro InoueHiroshi Kitakoji
Jan 23, 2016·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Blanca de la Cruz TorresJosé Naranjo Orellana
Feb 7, 2017·International Journal of Environmental Research and Public Health·Chung-Yen LuPei-Chun Chen
Jan 31, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Paula García BermejoManuel Albornoz Cabello

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