A hypothetical anti-neoplastic mechanism associated to reserve cells

Journal of Theoretical Biology
Antonio Torres-Montaner, David Hughes

Abstract

Reserve-stem cells, the permanent cells of body tissues, are thought to be the progenitor cells of cancer. This concept originates from the assumption that accumulation of somatic mutations necessary for malignant transformation can only take place in cellular targets with a prolonged life span. The progeny of reserve cells entering the differentiative pathway would be protected from potential critical mutations happening later than the reserve cell stage by normal cell population replacement unless possible targets would escape the replacement process by further mutations extending the cell's life span, impairment of physiological apoptosis. The existence of a mechanism for maintenance of genetic integrity in stem/reserve cells has previously been proposed. This mechanism differs from already identified DNA repair systems and, potentially, could prevent malignant transformation at the reserve cell stage, counteracting the expected high propensity of stem/reserve cells to neoplastic proliferation. Here, we show some histopathological observations suggesting that an anti-cancer mechanism might be associated to reserve/stem cells and that it could be responsible for huge differences in cancer incidence between closely related bod...Continue Reading

References

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Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 22, 2003·Cancer Letters·Chantal DesmazeLaure Sabatier

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Citations

Nov 17, 2006·Nature Reviews. Cancer·Lauren M F MerloCarlo C Maley
Mar 23, 2011·Critical Reviews in Oncology/hematology·Antonio Torres-Montaner
Jan 24, 2009·Pediatric Blood & Cancer·Sam W Moore
Jun 13, 2006·Molecular and Cellular Biochemistry·Vipen BatraKaushala P Mishra
Nov 6, 2021·Biomarker Research·A Torres-Montaner

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