PMID: 25742181DOI: 10.1039/c4dt03983aMar 6, 2015Paper
A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione
Dalton Transactions : an International Journal of Inorganic Chemistry
Kallol PurkaitArindam Mukherjee
Abstract
A slow hydrolyzing imidazole-based Ru(II)-arene complex [(L)Ru(II)(η(6)-p-cym)(Cl)](PF6) (1) with excellent stability in the extracellular chloride concentration shows better activity under hypoxia and strong resistance to glutathione (GSH) in vitro under hypoxic conditions. 1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis.
References
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·S Tsuchida, K Sato
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·A M OttoH G Mannherz
Aug 15, 1997·Science·S L AnzickP S Meltzer
Oct 19, 2000·Experimental Cell Research·H D HalickaZ Darzynkiewicz
Feb 19, 2002·Trends in Cell Biology·Jianhua Zhang, Ming Xu
Mar 21, 2002·Journal of the American Chemical Society·Haimei ChenPeter J Sadler
Jun 27, 2002·British Journal of Cancer·R E AirdD I Jodrell
Aug 9, 2002·Endocrine·Shelley BrownMurray Hong
Aug 20, 2002·Inorganic Chemistry·Fuyi WangPeter J Sadler
Jan 8, 2003·Journal of the American Chemical Society·Haimei ChenPeter J Sadler
Mar 13, 2003·Chemical Reviews·Miguel A FuertesJosé M Pérez
Oct 1, 2003·Biochemistry·Olga NovakovaViktor Brabec
Dec 4, 2003·British Journal of Cancer·S KochC Bokemeyer
Sep 7, 2004·The Journal of Biological Chemistry·Luis A Ralat, Roberta F Colman
Dec 8, 2004·Current Topics in Medicinal Chemistry·Enzo AlessioGianni Sava
Jun 10, 2005·Journal of Medicinal Chemistry·Claudine ScolaroPaul J Dyson
Jul 26, 2005·Cancer Letters·Susanne KapitzaBrigitte Marian
Dec 15, 2005·Journal of the American Chemical Society·Fuyi WangPeter J Sadler
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fuyi WangPeter J Sadler
Mar 22, 2006·Oncogene·C C McIlwainK D Tew
Jun 30, 2006·Chemistry : a European Journal·Hong-Ke LiuPeter J Sadler
Dec 13, 2006·Journal of Medicinal Chemistry·Abraha HabtemariamPeter J Sadler
Dec 19, 2006·Inorganic Chemistry·Sarah J DouganPeter J Sadler
Apr 4, 2007·Journal of Medicinal Chemistry·Michael GroesslBernhard K Keppler
Dec 22, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Michael A JakupecBernhard K Keppler
May 30, 2008·Nature·Ferdia A GallagherKevin M Brindle
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah J DouganPeter J Sadler
Jun 9, 2009·Bioorganic & Medicinal Chemistry Letters·Thomas RyckmansTim Young
Sep 29, 2009·Drug Discovery Today·Sabine H van Rijt, Peter J Sadler
Oct 13, 2009·Chemistry : a European Journal·Wolfgang KandiollerBernhard K Keppler
Dec 18, 2009·Journal of Cellular and Molecular Medicine·Johanna ChicheJacques Pouysségur
Aug 14, 2010·Inorganic Chemistry·Muhammad HanifChristian G Hartinger
Feb 1, 2011·Antioxidants & Redox Signaling·Ute JungwirthPetra Heffeter
Nov 15, 2011·Chemistry : a European Journal·Cesar M MannaEdit Y Tshuva
Dec 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Felix Kratz, Bakheet Elsadek
Dec 30, 2011·Journal of Medicinal Chemistry·Francesco CarusoClaudio Pettinari
Jul 14, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Soledad Betanzos-LaraAbraha Habtemariam
Oct 19, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Fuyi WangPeter J Sadler
Nov 10, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Kelly J KilpinPaul J Dyson
Jan 9, 2014·Inorganic Chemistry·Zahra AlmodaresPatrick C McGowan
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Citations
Jun 24, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Sudipta BhattacharyyaArindam Mukherjee
Apr 28, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Kallol PurkaitArindam Mukherjee
Jun 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Stefan RichterEvamarie Hey-Hawkins
Jul 16, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Joseph P ByrneMartin Albrecht
Sep 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashaparna Mondal, Priyankar Paira
Dec 24, 2018·Chemical Society Reviews·Amit SharmaJong Seung Kim
Jan 9, 2020·Journal of Inorganic Biochemistry·Subhendu KarmakarArindam Mukherjee
Dec 24, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashaparna MondalPriyankar Paira
May 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Durairaj GopalakrishnanMani Ganeshpandian
Jul 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Binoy KarPriyankar Paira
Oct 29, 2019·Inorganic Chemistry·Kallol PurkaitArnab Gupta
Jun 29, 2018·Inorganic Chemistry·Jian ZhaoGang Xu
Apr 17, 2020·Inorganic Chemistry·Arpan MukherjeeArindam Mukherjee
Sep 23, 2021·Chemistry, an Asian Journal·Arpan MukherjeeArindam Mukherjee
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