A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione

Dalton Transactions : an International Journal of Inorganic Chemistry
Kallol PurkaitArindam Mukherjee

Abstract

A slow hydrolyzing imidazole-based Ru(II)-arene complex [(L)Ru(II)(η(6)-p-cym)(Cl)](PF6) (1) with excellent stability in the extracellular chloride concentration shows better activity under hypoxia and strong resistance to glutathione (GSH) in vitro under hypoxic conditions. 1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis.

References

Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·S Tsuchida, K Sato
Oct 19, 2000·Experimental Cell Research·H D HalickaZ Darzynkiewicz
Feb 19, 2002·Trends in Cell Biology·Jianhua Zhang, Ming Xu
Aug 20, 2002·Inorganic Chemistry·Fuyi WangPeter J Sadler
Dec 8, 2004·Current Topics in Medicinal Chemistry·Enzo AlessioGianni Sava
Jun 10, 2005·Journal of Medicinal Chemistry·Claudine ScolaroPaul J Dyson
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fuyi WangPeter J Sadler
Jun 30, 2006·Chemistry : a European Journal·Hong-Ke LiuPeter J Sadler
Dec 22, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Michael A JakupecBernhard K Keppler
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah J DouganPeter J Sadler
Dec 18, 2009·Journal of Cellular and Molecular Medicine·Johanna ChicheJacques Pouysségur
Feb 1, 2011·Antioxidants & Redox Signaling·Ute JungwirthPetra Heffeter
Dec 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Felix Kratz, Bakheet Elsadek
Jul 14, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Soledad Betanzos-LaraAbraha Habtemariam
Oct 19, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Fuyi WangPeter J Sadler
Nov 10, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Kelly J KilpinPaul J Dyson
Jan 9, 2014·Inorganic Chemistry·Zahra AlmodaresPatrick C McGowan

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Citations

Jun 24, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Sudipta BhattacharyyaArindam Mukherjee
Apr 28, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Kallol PurkaitArindam Mukherjee
Jun 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Stefan RichterEvamarie Hey-Hawkins
Jul 16, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Joseph P ByrneMartin Albrecht
Sep 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashaparna Mondal, Priyankar Paira
Dec 24, 2018·Chemical Society Reviews·Amit SharmaJong Seung Kim
Jan 9, 2020·Journal of Inorganic Biochemistry·Subhendu KarmakarArindam Mukherjee
Dec 24, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashaparna MondalPriyankar Paira
May 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Durairaj GopalakrishnanMani Ganeshpandian
Jul 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Binoy KarPriyankar Paira

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