A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.

Proceedings of the National Academy of Sciences of the United States of America
Arpita BhurkeIndrani C Bagchi

Abstract

Implantation is initiated when an embryo attaches to the uterine luminal epithelium and subsequently penetrates into the underlying stroma to firmly embed in the endometrium. These events are followed by the formation of an extensive vascular network in the stroma that supports embryonic growth and ensures successful implantation. Interestingly, in many mammalian species, these processes of early pregnancy occur in a hypoxic environment. However, the mechanisms underlying maternal adaptation to hypoxia during early pregnancy remain unclear. In this study, using a knockout mouse model, we show that the transcription factor hypoxia-inducible factor 2 alpha (Hif2α), which is induced in subluminal stromal cells at the time of implantation, plays a crucial role during early pregnancy. Indeed, when preimplantation endometrial stromal cells are exposed to hypoxic conditions in vitro, we observed a striking enhancement in HIF2α expression. Further studies revealed that HIF2α regulates the expression of several metabolic and protein trafficking factors, including RAB27B, at the onset of implantation. RAB27B is a member of the Rab family of GTPases that allows controlled release of secretory granules. These granules are involved in traff...Continue Reading

References

Jan 1, 1978·Ciba Foundation Symposium·J Van BlerkomH Bell
Oct 1, 1978·The Journal of Experimental Zoology·P Quinn, G M Harlow
Dec 1, 1975·Journal of Reproduction and Fertility·J R Hinchliffe, A M El-Shershaby
Dec 1, 1966·Journal of Reproduction and Fertility·K Yoshinaga, C E Adams
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Oct 1, 1996·Human Reproduction·L A Salamonsen, D E Woolley
Feb 25, 1998·Biology of Reproduction·M J SoaresG Dai
Mar 2, 1999·Reviews of Reproduction·L A Salamonsen
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G MurphyJ Gavrilovic
Feb 29, 2000·Molecular Human Reproduction·P VuorelaE Halmesmäki
Jun 9, 2000·Annual Review of Physiology·M B Renfree, G Shaw
Dec 22, 2000·Genes & Development·D M AdelmanE Maltepe
Mar 29, 2003·Physiological Reviews·Robert D Burgoyne, Alan Morgan
Apr 23, 2003·Biochemical and Biophysical Research Communications·Takahisa TakinoHiroshi Sato
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Andrew M Sharkey, Stephen K Smith
Feb 1, 2005·Genesis : the Journal of Genetics and Development·Selma M SoyalJohn P Lydon
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey
Sep 30, 2006·Reproductive Biomedicine Online·Errol R Norwitz
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Amir WeissEliezer Shalev
Mar 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tanya TolmachovaMiguel C Seabra
May 1, 2007·Regenerative Medicine·Kelly Okazaki, Emin Maltepe
May 23, 2007·Molecular and Cellular Biology·Kevin Y LeeFrancesco J DeMayo
Jan 18, 2008·Developmental Biology·Gracy X RosarioMichael J Soares
Jan 28, 2010·Seminars in Reproductive Medicine·Cyril Y RamathalMilan K Bagchi
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M BeallYong Tang Zheng
Oct 12, 2010·Current Opinion in Obstetrics & Gynecology·Eric JauniauxGraham J Burton
Dec 2, 2010·Nature Reviews. Neuroscience·Todd C Sacktor
Dec 12, 2012·Nature Medicine·Jeeyeon ChaSudhansu K Dey
Jan 8, 2013·Molecular Aspects of Medicine·Shuang ZhangD Randall Armant
Jul 24, 2013·The Journal of Cell Biology·Francis A Barr
Sep 3, 2013·Seminars in Cell & Developmental Biology·Y M Vasquez, F J DeMayo

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.