A hypoxic ticket to the bone metastatic niche

Breast Cancer Research : BCR
Sakari Vanharanta

Abstract

Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention.

References

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Nov 22, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tingting YanJinsong Lu
Mar 13, 2012·BMC Biology·Arthur D LanderThordur Oskarsson
May 3, 2013·Cancer Metastasis Reviews·Jaclyn SceneayAndreas Möller
Oct 19, 2013·Cancer Cell·Sakari Vanharanta, Joan Massagué
Mar 13, 2014·Cell Stem Cell·Thordur OskarssonJoan Massagué

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Citations

Aug 22, 2017·The EPMA Journal·Ivica SmokovskiOlga Golubnitschaja
Jul 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Olga GolubnitschajaGodfrey Grech
Sep 1, 2016·Personalized Medicine·Jella-Andrea Abraham, Olga Golubnitschaja
Jul 1, 2016·Personalized Medicine·Jella-Andrea AbrahamOlga Golubnitschaja
Aug 10, 2021·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja

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