A joint application of spectroscopic, electrochemical and theoretical approaches in evaluation of the radical scavenging activity of 3-OH flavones and their iron complexes towards different radical species

Dalton Transactions : an International Journal of Inorganic Chemistry
Jasmina M Dimitrić MarkovićMiloš Mojović

Abstract

Combined spectroscopic (UV/visible, MS and EPR), electrochemical (CV) and theoretical approaches were used to evaluate the relevant interactions of morin and quercetin, as well as their respective iron(III) complexes with DPPH, tempone, hydroxyl and superoxide radicals. The results on iron complexation specify the stoichiometry and the relevant structural forms entering the chelation of the molecules. The spectroscopic DPPH assay shows better antioxidant activity of quercetin and its iron complex both in terms of EC(50) values and stoichiometry. The results of 2-deoxyribose degradation suggest that antioxidant activities of morin and quercetin may originate from their combined effect of iron chelation and radical scavenging. The distinctive difference in the EPR spectra of morin and quercetin radicals suggests different positions of the radical centers which may account for different sequences of their activities towards investigated radicals. Activity ranking of quercetin and morin, established by cyclic voltammetry, confirms their activity sequence obtained by EPR results and is also in agreement with the results of conformational analysis. The equilibrium geometries, optimized with the M052X functionals and 6-311G(d,p) basis...Continue Reading

References

Sep 8, 1978·Science·I Fridovich
Jan 1, 1990·Free Radical Biology & Medicine·Y T ChenY Ju
Jan 1, 1995·Life Sciences·T W WuR D Weisel
Jul 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B HalliwellO I Aruoma
Feb 14, 1995·Biochemical Pharmacology·T W WuN Camerman
Jan 1, 1996·Free Radical Biology & Medicine·S A van AckerA Bast
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Dec 1, 1996·Chemical Research in Toxicology·S A van AckerA Bast
Jul 27, 1999·Life Sciences·G Di CarloF Capasso
Sep 25, 1999·International Journal of Cancer. Journal International Du Cancer·K KawabataH Mori
Jul 17, 2001·Journal of Agricultural and Food Chemistry·D P Makris, J T Rossiter
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Jan 23, 2002·Chemico-biological Interactions·Petr HodekMarie Stiborová
Jan 23, 2003·Journal of Agricultural and Food Chemistry·Pascale GoupyOlivier Dangles
Aug 12, 2005·Chemical Reviews·Jacopo TomasiRoberto Cammi
Feb 18, 2006·Free Radical Research·Hakima El HajjiOlivier Dangles
Apr 8, 2006·The Journal of Physical Chemistry. a·Velmurugan ThavasiRyan Phillip Anthony Bettens
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Maolin GuoN D Chasteen
Jun 7, 2008·Chemical Communications : Chem Comm·Elizabeth Anne HillardChristian Amatore
Mar 12, 2009·The Journal of Organic Chemistry·Malgorzata MusialikGrzegorz Litwinienko
Mar 25, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Jasmina M Dimitrić MarkovićNenad D Filipović

❮ Previous
Next ❯

Citations

Oct 15, 2021·Biological Trace Element Research·Fredson Torres Silva, Breno Pannia Espósito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.