Abstract
As other neurodegenerative diseases, Alzheimer's disease, the most frequent dementia in the elderly, is characterized by multiple progressive impairments in the brain structure and in clinical functions such as cognitive functioning and functional disability. Until recently, these components were mostly studied independently because no joint model for multivariate longitudinal data and time to event was available in the statistical community. Yet, these components are fundamentally interrelated in the degradation process toward dementia and should be analyzed together. We thus propose a joint model to simultaneously describe the dynamics of multiple correlated components. Each component, defined as a latent process, is measured by one or several continuous markers (not necessarily Gaussian). Rather than considering the associated time to diagnosis as in standard joint models, we assume diagnosis corresponds to the passing above a covariate-specific threshold (to be estimated) of a pathological process that is modeled as a combination of the component-specific latent processes. This definition captures the clinical complexity of diagnoses such as dementia diagnosis but also benefits from simplifications for the computation of ma...Continue Reading
References
Dec 1, 1994·International Journal of Epidemiology·L LetenneurP Barberger-Gateau
Sep 5, 2002·Statistics in Medicine·Haiqun LinSusan T Mayne
Aug 22, 2006·Biometrics·Yueh-Yun Chi, Joseph G Ibrahim
Dec 13, 2006·Biometrics·Cécile ProustDaniel Commenges
Sep 18, 2007·Lifetime Data Analysis·Julien GaniayreLuc Letenneur
Jul 18, 2008·Cerebral Cortex·Bradford C DickersonRandy L Buckner
Dec 11, 2008·Annals of Neurology·Hélène AmievaJean François Dartigues
Sep 23, 2011·The Annals of Applied Statistics·Paul S Albert, Joanna H Shih
Oct 4, 2011·American Journal of Epidemiology·Cécile Proust-LimaHélène Jacqmin-Gadda
Feb 22, 2012·Statistics in Medicine·Ning LiChi-Hong Tseng
Oct 23, 2012·The British Journal of Mathematical and Statistical Psychology·Cécile Proust-LimaHélène Jacqmin-Gadda
Jan 22, 2013·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Apr 18, 2013·Statistical Methods in Medical Research·Bo He, Sheng Luo
Sep 7, 2013·Statistics in Medicine·Sheng Luo
Mar 29, 2014·Statistics in Medicine·Eleni-Rosalina AndrinopoulouEmmanuel Lesaffre
Jul 22, 2014·Statistics in Medicine·Danjie ZhangWei Shen
Sep 13, 2014·Journal of Applied Statistics·Jiin ChoiWesley K Thompson
Nov 19, 2014·Statistics in Medicine·An-Min Tang, Nian-Sheng Tang
Apr 8, 2015·The International Journal of Biostatistics·Daniel CommengesBenoit Liquet
Apr 14, 2015·Journal of the Royal Statistical Society. Series B, Statistical Methodology·Jessica BarrettDavid Taylor-Robinson
Sep 18, 2015·Statistics in Medicine·Cécile Proust-LimaHélène Jacqmin-Gadda
Apr 20, 2016·Statistics in Medicine·Loïc FerrerCécile Proust-Lima
Sep 9, 2016·BMC Medical Research Methodology·Graeme L HickeyRuwanthi Kolamunnage-Dona