A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy.

Beilstein Journal of Organic Chemistry
Steven C. Zimmerman

Abstract

This review summarizes part of the author's research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially molecular tweezers. Although designed to complex DNA, these hosts proved more applicable to the field of host-guest chemistry. This early experience and interest in intercalation ultimately led to the current efforts to develop small molecule therapeutic agents for myotonic dystrophy using a rational design approach that heavily relies on principles of supramolecular chemistry. How this work was influenced by that of others in the field and the evolution of each area of research is highlighted with selected examples.

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Citations

Jul 7, 2018·Nature Reviews. Drug Discovery·Katherine Deigan WarnerKevin M Weeks
May 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amira MbarekJeanne Leblond Chain
Apr 25, 2020·ChemistryOpen·Mathieu Surin, Sébastien Ulrich
Dec 19, 2020·The Journal of Biological Chemistry·Aline Umuhire Juru, Amanda E Hargrove
May 28, 2021·Chemical Science·Pim J de VinkLuc Brunsveld
Oct 19, 2017·Journal of the American Chemical Society·David BierChristian Ottmann

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Methods Mentioned

BETA
X-ray
NMR
electrophoretic mobility shift assay
transgenic

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